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Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials.

Publication ,  Journal Article
Ellingson, BM; Bendszus, M; Boxerman, J; Barboriak, D; Erickson, BJ; Smits, M; Nelson, SJ; Gerstner, E; Alexander, B; Goldmacher, G; Wick, W ...
Published in: Neuro Oncol
September 2015

A recent joint meeting was held on January 30, 2014, with the US Food and Drug Administration (FDA), National Cancer Institute (NCI), clinical scientists, imaging experts, pharmaceutical and biotech companies, clinical trials cooperative groups, and patient advocate groups to discuss imaging endpoints for clinical trials in glioblastoma. This workshop developed a set of priorities and action items including the creation of a standardized MRI protocol for multicenter studies. The current document outlines consensus recommendations for a standardized Brain Tumor Imaging Protocol (BTIP), along with the scientific and practical justifications for these recommendations, resulting from a series of discussions between various experts involved in aspects of neuro-oncology neuroimaging for clinical trials. The minimum recommended sequences include: (i) parameter-matched precontrast and postcontrast inversion recovery-prepared, isotropic 3D T1-weighted gradient-recalled echo; (ii) axial 2D T2-weighted turbo spin-echo acquired after contrast injection and before postcontrast 3D T1-weighted images to control timing of images after contrast administration; (iii) precontrast, axial 2D T2-weighted fluid-attenuated inversion recovery; and (iv) precontrast, axial 2D, 3-directional diffusion-weighted images. Recommended ranges of sequence parameters are provided for both 1.5 T and 3 T MR systems.

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Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

September 2015

Volume

17

Issue

9

Start / End Page

1188 / 1198

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neuroimaging
  • Magnetic Resonance Imaging
  • Image Enhancement
  • Humans
  • Contrast Media
  • Clinical Trials as Topic
  • Clinical Protocols
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis
 

Citation

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Ellingson, B. M., Bendszus, M., Boxerman, J., Barboriak, D., Erickson, B. J., Smits, M., … Jumpstarting Brain Tumor Drug Development Coalition Imaging Standardization Steering Committee, . (2015). Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials. Neuro Oncol, 17(9), 1188–1198. https://doi.org/10.1093/neuonc/nov095
Ellingson, Benjamin M., Martin Bendszus, Jerrold Boxerman, Daniel Barboriak, Bradley J. Erickson, Marion Smits, Sarah J. Nelson, et al. “Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials.Neuro Oncol 17, no. 9 (September 2015): 1188–98. https://doi.org/10.1093/neuonc/nov095.
Ellingson BM, Bendszus M, Boxerman J, Barboriak D, Erickson BJ, Smits M, et al. Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials. Neuro Oncol. 2015 Sep;17(9):1188–98.
Ellingson, Benjamin M., et al. “Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials.Neuro Oncol, vol. 17, no. 9, Sept. 2015, pp. 1188–98. Pubmed, doi:10.1093/neuonc/nov095.
Ellingson BM, Bendszus M, Boxerman J, Barboriak D, Erickson BJ, Smits M, Nelson SJ, Gerstner E, Alexander B, Goldmacher G, Wick W, Vogelbaum M, Weller M, Galanis E, Kalpathy-Cramer J, Shankar L, Jacobs P, Pope WB, Yang D, Chung C, Knopp MV, Cha S, van den Bent MJ, Chang S, Yung WKA, Cloughesy TF, Wen PY, Gilbert MR, Jumpstarting Brain Tumor Drug Development Coalition Imaging Standardization Steering Committee. Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials. Neuro Oncol. 2015 Sep;17(9):1188–1198.
Journal cover image

Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

September 2015

Volume

17

Issue

9

Start / End Page

1188 / 1198

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neuroimaging
  • Magnetic Resonance Imaging
  • Image Enhancement
  • Humans
  • Contrast Media
  • Clinical Trials as Topic
  • Clinical Protocols
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis