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Can we observe epigenetic effects on human brain function?

Publication ,  Journal Article
Nikolova, YS; Hariri, AR
Published in: Trends in cognitive sciences
July 2015

Imaging genetics has identified many contributions of DNA sequence variation to individual differences in brain function, behavior, and risk for psychopathology. Recent studies have extended this work beyond the genome by mapping epigenetic differences, specifically gene methylation in peripherally assessed DNA, onto variability in behaviorally and clinically relevant brain function. These data have generated understandable enthusiasm for the potential of such research to illuminate biological mechanisms of risk. We use our research on the effects of genetic and epigenetic variation in the human serotonin transporter on brain function to generate a guardedly optimistic opinion that the available data encourage continued research in this direction, and suggest strategies to promote faster progress.

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Published In

Trends in cognitive sciences

DOI

EISSN

1879-307X

ISSN

1364-6613

Publication Date

July 2015

Volume

19

Issue

7

Start / End Page

366 / 373

Related Subject Headings

  • Serotonin Plasma Membrane Transport Proteins
  • Humans
  • Experimental Psychology
  • Epigenomics
  • Epigenesis, Genetic
  • Brain
  • 5204 Cognitive and computational psychology
  • 5203 Clinical and health psychology
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
 

Citation

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Nikolova, Y. S., & Hariri, A. R. (2015). Can we observe epigenetic effects on human brain function? Trends in Cognitive Sciences, 19(7), 366–373. https://doi.org/10.1016/j.tics.2015.05.003
Nikolova, Yuliya S., and Ahmad R. Hariri. “Can we observe epigenetic effects on human brain function?Trends in Cognitive Sciences 19, no. 7 (July 2015): 366–73. https://doi.org/10.1016/j.tics.2015.05.003.
Nikolova YS, Hariri AR. Can we observe epigenetic effects on human brain function? Trends in cognitive sciences. 2015 Jul;19(7):366–73.
Nikolova, Yuliya S., and Ahmad R. Hariri. “Can we observe epigenetic effects on human brain function?Trends in Cognitive Sciences, vol. 19, no. 7, July 2015, pp. 366–73. Epmc, doi:10.1016/j.tics.2015.05.003.
Nikolova YS, Hariri AR. Can we observe epigenetic effects on human brain function? Trends in cognitive sciences. 2015 Jul;19(7):366–373.
Journal cover image

Published In

Trends in cognitive sciences

DOI

EISSN

1879-307X

ISSN

1364-6613

Publication Date

July 2015

Volume

19

Issue

7

Start / End Page

366 / 373

Related Subject Headings

  • Serotonin Plasma Membrane Transport Proteins
  • Humans
  • Experimental Psychology
  • Epigenomics
  • Epigenesis, Genetic
  • Brain
  • 5204 Cognitive and computational psychology
  • 5203 Clinical and health psychology
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences