Can we observe epigenetic effects on human brain function?

Journal Article (Review;Journal Article)

Imaging genetics has identified many contributions of DNA sequence variation to individual differences in brain function, behavior, and risk for psychopathology. Recent studies have extended this work beyond the genome by mapping epigenetic differences, specifically gene methylation in peripherally assessed DNA, onto variability in behaviorally and clinically relevant brain function. These data have generated understandable enthusiasm for the potential of such research to illuminate biological mechanisms of risk. We use our research on the effects of genetic and epigenetic variation in the human serotonin transporter on brain function to generate a guardedly optimistic opinion that the available data encourage continued research in this direction, and suggest strategies to promote faster progress.

Full Text

Duke Authors

Cited Authors

  • Nikolova, YS; Hariri, AR

Published Date

  • July 2015

Published In

Volume / Issue

  • 19 / 7

Start / End Page

  • 366 - 373

PubMed ID

  • 26051383

Pubmed Central ID

  • PMC4486509

Electronic International Standard Serial Number (EISSN)

  • 1879-307X

International Standard Serial Number (ISSN)

  • 1364-6613

Digital Object Identifier (DOI)

  • 10.1016/j.tics.2015.05.003


  • eng