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Modified INOvent for delivery of inhaled nitric oxide during cardiac MRI.

Publication ,  Journal Article
Devendra, GP; Hart, SA; Kim, YY; Setser, RM; Flamm, SD; Krasuski, RA
Published in: Magn Reson Imaging
October 2011

BACKGROUND: The aim of this study was to assess the feasibility of delivering NO through a modified system to allow clearance of the magnetic field and thus compatibility with cardiac magnetic resonance (CMR). Nitric oxide (NO) is an inhalational, selective pulmonary vasodilator with a wide range of applications in a variety of disease states, including diseases that affect the right ventricle. Accurate assessment of dynamic changes in right ventricular function necessitates CMR; however, delivery of NO is only possible using equipment that is not magnetic resonance imaging (MRI) compatible (INOvent delivery system, Ohmeda, Inc., Madison, WI, USA). METHODS: The INOvent delivery system was modified by using 35 ft. of standard oxygen tubing to allow NO delivery through an electrical conduit and into the MRI suite. The concentrations of oxygen (O(2)), nitrogen dioxide (a harmful byproduct, NO(2)) and NO were measured in triplicate using the built-in electrochemical analyzer on the INOvent. After confirmation of safety, the system was used to administer drug to a patient x, and dynamic MRI measurements were performed. RESULTS: When the standard INOvent was set to administer 40 ppm of NO, the mean/standard deviation of gas delivered was as follows: NO: 42/0 ppm; NO(2): 0.3/0.1 ppm; and O(2): 93/0 ppm. In comparison, the gas delivery of the modified INOvent was follows: NO: 41/0 ppm; NO(2): 0.5/0 ppm; and O(2): 93.7/0.6 ppm. During administration to an index patient with severe pulmonic insufficiency (PI), a measurable reduction in PI was observed by CMR. CONCLUSIONS: Nitric oxide can be administered through 35 ft. of standard oxygen tubing without significantly affecting dose delivery. This technique has potential application in patients with right-sided structural heart disease for determination of dynamic physiological changes.

Duke Scholars

Published In

Magn Reson Imaging

DOI

EISSN

1873-5894

Publication Date

October 2011

Volume

29

Issue

8

Start / End Page

1145 / 1149

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Tetralogy of Fallot
  • Systole
  • Pulmonary Valve
  • Oxygen
  • Nuclear Medicine & Medical Imaging
  • Nitric Oxide
  • Myocardium
  • Male
  • Magnetic Resonance Imaging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Devendra, G. P., Hart, S. A., Kim, Y. Y., Setser, R. M., Flamm, S. D., & Krasuski, R. A. (2011). Modified INOvent for delivery of inhaled nitric oxide during cardiac MRI. Magn Reson Imaging, 29(8), 1145–1149. https://doi.org/10.1016/j.mri.2011.05.008
Devendra, Ganesh P., Stephen A. Hart, Yuli Y. Kim, Randy M. Setser, Scott D. Flamm, and Richard A. Krasuski. “Modified INOvent for delivery of inhaled nitric oxide during cardiac MRI.Magn Reson Imaging 29, no. 8 (October 2011): 1145–49. https://doi.org/10.1016/j.mri.2011.05.008.
Devendra GP, Hart SA, Kim YY, Setser RM, Flamm SD, Krasuski RA. Modified INOvent for delivery of inhaled nitric oxide during cardiac MRI. Magn Reson Imaging. 2011 Oct;29(8):1145–9.
Devendra, Ganesh P., et al. “Modified INOvent for delivery of inhaled nitric oxide during cardiac MRI.Magn Reson Imaging, vol. 29, no. 8, Oct. 2011, pp. 1145–49. Pubmed, doi:10.1016/j.mri.2011.05.008.
Devendra GP, Hart SA, Kim YY, Setser RM, Flamm SD, Krasuski RA. Modified INOvent for delivery of inhaled nitric oxide during cardiac MRI. Magn Reson Imaging. 2011 Oct;29(8):1145–1149.
Journal cover image

Published In

Magn Reson Imaging

DOI

EISSN

1873-5894

Publication Date

October 2011

Volume

29

Issue

8

Start / End Page

1145 / 1149

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Tetralogy of Fallot
  • Systole
  • Pulmonary Valve
  • Oxygen
  • Nuclear Medicine & Medical Imaging
  • Nitric Oxide
  • Myocardium
  • Male
  • Magnetic Resonance Imaging