Impact of fibrinogen levels on angiographic progression and 12-year survival in the armed forces regression study.


Journal Article

We assessed the role of fibrinogen levels on angiographic progression and long-term survival among 111 patients with coronary disease enrolled in the Armed Forces Regression Study (AFREGS). Baseline fibrinogen levels and quantitative coronary angiography were performed initially and at 30 months. Progression or nonregression of coronary disease was more prevalent in patients with high fibrinogen than patients with normal fibrinogen (66.1% vs 45.5%; P = .022). Twelve-year cardiovascular (CV) mortality was substantially higher if fibrinogen was elevated (17.9% vs 3.6%, P = .016). Among patients with elevated fibrinogen and angiographic progression or nonregression, there were 10 deaths and all were CV. Elevated levels of fibrinogen predict the angiographic progression of existing coronary disease and likelihood of CV death. Among patients with elevated levels of fibrinogen, angiographic progression identifies a significantly increased likelihood of a fatal CV event.

Full Text

Duke Authors

Cited Authors

  • Devendra, GP; Hart, SA; Whitney, EJ; Krasuski, RA

Published Date

  • May 2010

Published In

Volume / Issue

  • 61 / 4

Start / End Page

  • 333 - 337

PubMed ID

  • 20304867

Pubmed Central ID

  • 20304867

Electronic International Standard Serial Number (EISSN)

  • 1940-1574

Digital Object Identifier (DOI)

  • 10.1177/0003319709360525


  • eng

Conference Location

  • United States