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Optimal timing of hydration to erase contrast-associated nephropathy: the OTHER CAN study.

Publication ,  Journal Article
Krasuski, RA; Beard, BM; Geoghagan, JD; Thompson, CM; Guidera, SA
Published in: J Invasive Cardiol
December 2003

Intravascular contrast agents remain a common cause of acute renal dysfunction, and prolonged intravenous saline administration prior to contrast exposure has been recommended in patients with elevated creatinine levels. For patient convenience and to minimize cost, same-day procedures have become common in patients with moderate renal insufficiency, despite little evidence to support this practice. A randomized trial was therefore performed to compare overnight hydration with bolus hydration in patients with moderate renal insufficiency. Although no overall change in creatinine was seen at 24 or 48 hours, four of the 37 patients (10.8%) in the bolus group versus none of the 26 in the overnight hydration group developed contrast associated nephropathy (CAN; p = 0.136). These results should at least question whether bolus hydration should be considered an equivalent alternative to overnight hydration in patients at risk for CAN undergoing angiography, and encourage further evaluation of this issue.

Duke Scholars

Published In

J Invasive Cardiol

ISSN

1042-3931

Publication Date

December 2003

Volume

15

Issue

12

Start / End Page

699 / 702

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Randomized Controlled Trials as Topic
  • Middle Aged
  • Male
  • Kidney Failure, Chronic
  • Kidney Diseases
  • Kidney
  • Humans
  • Heart Failure
 

Citation

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MLA
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Krasuski, R. A., Beard, B. M., Geoghagan, J. D., Thompson, C. M., & Guidera, S. A. (2003). Optimal timing of hydration to erase contrast-associated nephropathy: the OTHER CAN study. J Invasive Cardiol, 15(12), 699–702.
Krasuski, Richard A., Brian M. Beard, Jay D. Geoghagan, Christopher M. Thompson, and Stephen A. Guidera. “Optimal timing of hydration to erase contrast-associated nephropathy: the OTHER CAN study.J Invasive Cardiol 15, no. 12 (December 2003): 699–702.
Krasuski RA, Beard BM, Geoghagan JD, Thompson CM, Guidera SA. Optimal timing of hydration to erase contrast-associated nephropathy: the OTHER CAN study. J Invasive Cardiol. 2003 Dec;15(12):699–702.
Krasuski, Richard A., et al. “Optimal timing of hydration to erase contrast-associated nephropathy: the OTHER CAN study.J Invasive Cardiol, vol. 15, no. 12, Dec. 2003, pp. 699–702.
Krasuski RA, Beard BM, Geoghagan JD, Thompson CM, Guidera SA. Optimal timing of hydration to erase contrast-associated nephropathy: the OTHER CAN study. J Invasive Cardiol. 2003 Dec;15(12):699–702.

Published In

J Invasive Cardiol

ISSN

1042-3931

Publication Date

December 2003

Volume

15

Issue

12

Start / End Page

699 / 702

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Randomized Controlled Trials as Topic
  • Middle Aged
  • Male
  • Kidney Failure, Chronic
  • Kidney Diseases
  • Kidney
  • Humans
  • Heart Failure