Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure.


Journal Article

The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (MVO2) and thus improves LV mechanical efficiency in dogs with heart failure (HF). Ranolazine did not change MVO2 and LV mechanical efficiency increased (22.4+/-2.8% to 30.9+/-3.4% (P<0.05). In contrast, dobutamine significantly increased MVO2 and did not improve mechanical efficiency. Thus, short-term treatment with ranolazine improved LV function without an increase in MO2, resulting in an increased myocardial mechanical efficiency in dogs with HF.

Full Text

Duke Authors

Cited Authors

  • Chandler, MP; Stanley, WC; Morita, H; Suzuki, G; Roth, BA; Blackburn, B; Wolff, A; Sabbah, HN

Published Date

  • August 2002

Published In

Volume / Issue

  • 91 / 4

Start / End Page

  • 278 - 280

PubMed ID

  • 12193459

Pubmed Central ID

  • 12193459

Electronic International Standard Serial Number (EISSN)

  • 1524-4571

International Standard Serial Number (ISSN)

  • 0009-7330

Digital Object Identifier (DOI)

  • 10.1161/01.res.0000031151.21145.59


  • eng