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Racial differences in the prevalence of severe aortic stenosis.

Publication ,  Journal Article
Patel, DK; Green, KD; Fudim, M; Harrell, FE; Wang, TJ; Robbins, MA
Published in: J Am Heart Assoc
May 28, 2014

BACKGROUND: In an era of expanded treatment options for severe aortic stenosis, it is important to understand risk factors for the condition. It has been suggested that severe aortic stenosis is less common in African Americans, but there are limited data from large studies. METHODS AND RESULTS: The Synthetic Derivative at Vanderbilt University Medical Center, a database of over 2.1 million de-identified patient records, was used to identify individuals who had undergone echocardiography. The association of race with severe aortic stenosis was examined using multivariable logistic regression analyses adjusting for conventional risk factors. Of the 272 429 eligible patients (mean age 45 years, 44% male) with echocardiography, 14% were African American and 82% were Caucasian. Severe aortic stenosis was identified in 106 (0.29%) African-American patients and 2030 (0.91%) Caucasian patients (crude OR 0.32, 95% CI [0.26, 0.38]). This difference persisted in multivariable-adjusted analyses (OR 0.41 [0.33, 0.50], P<0.0001). African-American individuals were also less likely to have severe aortic stenosis due to degenerative calcific disease (adjusted OR 0.47 [0.36, 0.61]) or congenitally bicuspid valve (crude OR 0.13 [0.02, 0.80], adjusted OR dependent on age). Referral bias against those with severe valvular disease was assessed by comparing the prevalence of severe mitral regurgitation in Caucasians and African Americans and no difference was found. CONCLUSIONS: These findings suggest that African Americans are at significantly lower risk of developing severe aortic stenosis than Caucasians.

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Published In

J Am Heart Assoc

DOI

EISSN

2047-9980

Publication Date

May 28, 2014

Volume

3

Issue

3

Start / End Page

e000879

Location

England

Related Subject Headings

  • Young Adult
  • White People
  • Tennessee
  • Risk Factors
  • Prevalence
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Female
 

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Patel, D. K., Green, K. D., Fudim, M., Harrell, F. E., Wang, T. J., & Robbins, M. A. (2014). Racial differences in the prevalence of severe aortic stenosis. J Am Heart Assoc, 3(3), e000879. https://doi.org/10.1161/JAHA.114.000879
Patel, Devin K., Kelly D. Green, Marat Fudim, Frank E. Harrell, Thomas J. Wang, and Mark A. Robbins. “Racial differences in the prevalence of severe aortic stenosis.J Am Heart Assoc 3, no. 3 (May 28, 2014): e000879. https://doi.org/10.1161/JAHA.114.000879.
Patel DK, Green KD, Fudim M, Harrell FE, Wang TJ, Robbins MA. Racial differences in the prevalence of severe aortic stenosis. J Am Heart Assoc. 2014 May 28;3(3):e000879.
Patel, Devin K., et al. “Racial differences in the prevalence of severe aortic stenosis.J Am Heart Assoc, vol. 3, no. 3, May 2014, p. e000879. Pubmed, doi:10.1161/JAHA.114.000879.
Patel DK, Green KD, Fudim M, Harrell FE, Wang TJ, Robbins MA. Racial differences in the prevalence of severe aortic stenosis. J Am Heart Assoc. 2014 May 28;3(3):e000879.
Journal cover image

Published In

J Am Heart Assoc

DOI

EISSN

2047-9980

Publication Date

May 28, 2014

Volume

3

Issue

3

Start / End Page

e000879

Location

England

Related Subject Headings

  • Young Adult
  • White People
  • Tennessee
  • Risk Factors
  • Prevalence
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Female