Inflammation in coronary artery disease.

Published

Journal Article (Review)

Coronary artery disease (CAD) is the leading cause of death in the United States. Although CAD was formerly considered a lipid accumulation-mediated disease, it has now been clearly shown to involve an ongoing inflammatory response. Advances in basic science research have established the crucial role of inflammation in mediating all stages of CAD. Today, there is convincing evidence that multiple interrelated immune mechanisms interact with metabolic risk factors to initiate, promote, and ultimately activate lesions in the coronary arteries. This review aims to provide current evidence pertaining to the role of inflammation in the pathogenesis of CAD and discusses the impact of inflammatory markers and their modification on clinical outcomes.

Full Text

Duke Authors

Cited Authors

  • Christodoulidis, G; Vittorio, TJ; Fudim, M; Lerakis, S; Kosmas, CE

Published Date

  • November 2014

Published In

Volume / Issue

  • 22 / 6

Start / End Page

  • 279 - 288

PubMed ID

  • 24441047

Pubmed Central ID

  • 24441047

Electronic International Standard Serial Number (EISSN)

  • 1538-4683

International Standard Serial Number (ISSN)

  • 1061-5377

Digital Object Identifier (DOI)

  • 10.1097/crd.0000000000000006

Language

  • eng