Outcome of plasmapheresis in myasthenia gravis: delayed therapy is not favorable.


Journal Article

INTRODUCTION: The purpose of this study was to compare the in-hospital mortality and complication rates after early and delayed initiation of plasma exchange (PLEX) in patients with myasthenia gravis (MG). METHODS: Our cohort was identified from the Nationwide Inpatient Sample database for the years 2000 through 2005. Early treatment was defined as therapy with PLEX administered within the first 2 days from hospital admission. Univariate and multivariate analyses were employed. RESULTS: One thousand fifty-three patients were treated and included in the analysis. A delay in receiving PLEX was associated with higher mortality (6.56% vs. 1.15%, P < 0.001) and increased complications (29.51% vs. 15.29%, P < 0.001). Adjusted analysis showed increased mortality [odds ratio (OR) 2.812; 95% confidence interval (CI) 1.119-7.069] and complications (OR 1.672; 95% CI 1.118-2.501) with delayed PLEX therapy. CONCLUSIONS: Delaying PLEX therapy for MG by more than 2 days after admission may lead to higher mortality and complication rates, and thus prompt therapy is warranted.

Full Text

Cited Authors

  • Mandawat, A; Mandawat, A; Kaminski, HJ; Shaker, ZA; Alawi, AA; Alshekhlee, A

Published Date

  • April 2011

Published In

Volume / Issue

  • 43 / 4

Start / End Page

  • 578 - 584

PubMed ID

  • 21404289

Pubmed Central ID

  • 21404289

Electronic International Standard Serial Number (EISSN)

  • 1097-4598

Digital Object Identifier (DOI)

  • 10.1002/mus.21924


  • eng

Conference Location

  • United States