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Evaluation of hybrid algorithm for analysis of scattered light using ex vivo nuclear morphology measurements of cervical epithelium.

Publication ,  Journal Article
Ho, D; Drake, TK; Bentley, RC; Valea, FA; Wax, A
Published in: Biomed Opt Express
August 1, 2015

We evaluate a new hybrid algorithm for determining nuclear morphology using angle-resolved low coherence interferometry (a/LCI) measurements in ex vivo cervical tissue. The algorithm combines Mie theory based and continuous wavelet transform inverse light scattering analysis. The hybrid algorithm was validated and compared to traditional Mie theory based analysis using an ex vivo tissue data set. The hybrid algorithm achieved 100% agreement with pathology in distinguishing dysplastic and non-dysplastic biopsy sites in the pilot study. Significantly, the new algorithm performed over four times faster than traditional Mie theory based analysis.

Duke Scholars

Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

August 1, 2015

Volume

6

Issue

8

Start / End Page

2755 / 2765

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics
 

Citation

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MLA
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Ho, D., Drake, T. K., Bentley, R. C., Valea, F. A., & Wax, A. (2015). Evaluation of hybrid algorithm for analysis of scattered light using ex vivo nuclear morphology measurements of cervical epithelium. Biomed Opt Express, 6(8), 2755–2765. https://doi.org/10.1364/BOE.6.002755
Ho, Derek, Tyler K. Drake, Rex C. Bentley, Fidel A. Valea, and Adam Wax. “Evaluation of hybrid algorithm for analysis of scattered light using ex vivo nuclear morphology measurements of cervical epithelium.Biomed Opt Express 6, no. 8 (August 1, 2015): 2755–65. https://doi.org/10.1364/BOE.6.002755.
Ho D, Drake TK, Bentley RC, Valea FA, Wax A. Evaluation of hybrid algorithm for analysis of scattered light using ex vivo nuclear morphology measurements of cervical epithelium. Biomed Opt Express. 2015 Aug 1;6(8):2755–65.
Ho, Derek, et al. “Evaluation of hybrid algorithm for analysis of scattered light using ex vivo nuclear morphology measurements of cervical epithelium.Biomed Opt Express, vol. 6, no. 8, Aug. 2015, pp. 2755–65. Pubmed, doi:10.1364/BOE.6.002755.
Ho D, Drake TK, Bentley RC, Valea FA, Wax A. Evaluation of hybrid algorithm for analysis of scattered light using ex vivo nuclear morphology measurements of cervical epithelium. Biomed Opt Express. 2015 Aug 1;6(8):2755–2765.
Journal cover image

Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

August 1, 2015

Volume

6

Issue

8

Start / End Page

2755 / 2765

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics