Evaluation of hybrid algorithm for analysis of scattered light using ex vivo nuclear morphology measurements of cervical epithelium.
Published online
Journal Article
We evaluate a new hybrid algorithm for determining nuclear morphology using angle-resolved low coherence interferometry (a/LCI) measurements in ex vivo cervical tissue. The algorithm combines Mie theory based and continuous wavelet transform inverse light scattering analysis. The hybrid algorithm was validated and compared to traditional Mie theory based analysis using an ex vivo tissue data set. The hybrid algorithm achieved 100% agreement with pathology in distinguishing dysplastic and non-dysplastic biopsy sites in the pilot study. Significantly, the new algorithm performed over four times faster than traditional Mie theory based analysis.
Full Text
Duke Authors
Cited Authors
- Ho, D; Drake, TK; Bentley, RC; Valea, FA; Wax, A
Published Date
- August 1, 2015
Published In
Volume / Issue
- 6 / 8
Start / End Page
- 2755 - 2765
PubMed ID
- 26309741
Pubmed Central ID
- 26309741
International Standard Serial Number (ISSN)
- 2156-7085
Digital Object Identifier (DOI)
- 10.1364/BOE.6.002755
Language
- eng
Conference Location
- United States