Evaluation of hybrid algorithm for analysis of scattered light using ex vivo nuclear morphology measurements of cervical epithelium.

Published online

Journal Article

We evaluate a new hybrid algorithm for determining nuclear morphology using angle-resolved low coherence interferometry (a/LCI) measurements in ex vivo cervical tissue. The algorithm combines Mie theory based and continuous wavelet transform inverse light scattering analysis. The hybrid algorithm was validated and compared to traditional Mie theory based analysis using an ex vivo tissue data set. The hybrid algorithm achieved 100% agreement with pathology in distinguishing dysplastic and non-dysplastic biopsy sites in the pilot study. Significantly, the new algorithm performed over four times faster than traditional Mie theory based analysis.

Full Text

Duke Authors

Cited Authors

  • Ho, D; Drake, TK; Bentley, RC; Valea, FA; Wax, A

Published Date

  • August 1, 2015

Published In

Volume / Issue

  • 6 / 8

Start / End Page

  • 2755 - 2765

PubMed ID

  • 26309741

Pubmed Central ID

  • 26309741

International Standard Serial Number (ISSN)

  • 2156-7085

Digital Object Identifier (DOI)

  • 10.1364/BOE.6.002755


  • eng

Conference Location

  • United States