Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.

Journal Article (Journal Article;Review)

Protein acetylation is a well-studied regulatory mechanism for several cellular processes, ranging from gene expression to metabolism. Recent discoveries of new post-translational modifications, including malonylation, succinylation, and glutarylation, have expanded our understanding of the types of modifications found on proteins. These three acidic lysine modifications are structurally similar but have the potential to regulate different proteins in different pathways. The deacylase sirtuin 5 (SIRT5) catalyzes the removal of these modifications from a wide range of proteins in different subcellular compartments. Here, we review these new modifications, their regulation by SIRT5, and their emerging role in cellular regulation and diseases.

Full Text

Duke Authors

Cited Authors

  • Hirschey, MD; Zhao, Y

Published Date

  • September 2015

Published In

Volume / Issue

  • 14 / 9

Start / End Page

  • 2308 - 2315

PubMed ID

  • 25717114

Pubmed Central ID

  • PMC4563717

Electronic International Standard Serial Number (EISSN)

  • 1535-9484

Digital Object Identifier (DOI)

  • 10.1074/mcp.R114.046664


  • eng

Conference Location

  • United States