Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.
Protein acetylation is a well-studied regulatory mechanism for several cellular processes, ranging from gene expression to metabolism. Recent discoveries of new post-translational modifications, including malonylation, succinylation, and glutarylation, have expanded our understanding of the types of modifications found on proteins. These three acidic lysine modifications are structurally similar but have the potential to regulate different proteins in different pathways. The deacylase sirtuin 5 (SIRT5) catalyzes the removal of these modifications from a wide range of proteins in different subcellular compartments. Here, we review these new modifications, their regulation by SIRT5, and their emerging role in cellular regulation and diseases.
Duke Scholars
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- Sirtuins
- Proteins
- Protein Processing, Post-Translational
- NAD
- Lysine
- Intracellular Space
- Humans
- Gene Expression Regulation
- Biochemistry & Molecular Biology
- Animals
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Sirtuins
- Proteins
- Protein Processing, Post-Translational
- NAD
- Lysine
- Intracellular Space
- Humans
- Gene Expression Regulation
- Biochemistry & Molecular Biology
- Animals