Hierarchy of RNA functional dynamics.

Journal Article (Review)

RNA dynamics play a fundamental role in many cellular functions. However, there is no general framework to describe these complex processes, which typically consist of many structural maneuvers that occur over timescales ranging from picoseconds to seconds. Here, we classify RNA dynamics into distinct modes representing transitions between basins on a hierarchical free-energy landscape. These transitions include large-scale secondary-structural transitions at >0.1-s timescales, base-pair/tertiary dynamics at microsecond-to-millisecond timescales, stacking dynamics at timescales ranging from nanoseconds to microseconds, and other "jittering" motions at timescales ranging from picoseconds to nanoseconds. We review various modes within these three different tiers, the different mechanisms by which they are used to regulate function, and how they can be coupled together to achieve greater functional complexity.

Full Text

Duke Authors

Cited Authors

  • Mustoe, AM; Brooks, CL; Al-Hashimi, HM

Published Date

  • January 2014

Published In

Volume / Issue

  • 83 /

Start / End Page

  • 441 - 466

PubMed ID

  • 24606137

Electronic International Standard Serial Number (EISSN)

  • 1545-4509

International Standard Serial Number (ISSN)

  • 0066-4154

Digital Object Identifier (DOI)

  • 10.1146/annurev-biochem-060713-035524

Language

  • eng