NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings.

Journal Article (Review)

An increasing number of RNAs are being discovered that perform their functions by undergoing large changes in conformation in response to a variety of cellular signals, including recognition of proteins and small molecular targets, changes in temperature, and RNA synthesis itself. The measurement of NMR residual dipolar couplings (RDCs) in partially aligned systems is providing new insights into the structural plasticity of RNA through combined characterization of large-amplitude collective helix motions and local flexibility in noncanonical regions over a wide window of biologically relevant timescales (

Full Text

Duke Authors

Cited Authors

  • Getz, M; Sun, X; Casiano-Negroni, A; Zhang, Q; Al-Hashimi, HM

Published Date

  • August 2007

Published In

Volume / Issue

  • 86 / 5-6

Start / End Page

  • 384 - 402

PubMed ID

  • 17594140

Electronic International Standard Serial Number (EISSN)

  • 1097-0282

International Standard Serial Number (ISSN)

  • 0006-3525

Digital Object Identifier (DOI)

  • 10.1002/bip.20765

Language

  • eng