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Effects of striatal nitric oxide production on regional cerebral blood flow and seizure development in rats exposed to extreme hyperoxia.

Publication ,  Journal Article
Gasier, HG; Demchenko, IT; Allen, BW; Piantadosi, CA
Published in: J Appl Physiol (1985)
December 1, 2015

The endogenous vasodilator and signaling molecule nitric oxide has been implicated in cerebral hyperemia, sympathoexcitation, and seizures induced by hyperbaric oxygen (HBO2) at or above 3 atmospheres absolute (ATA). It is unknown whether these events in the onset of central nervous system oxygen toxicity originate within specific brain structures and whether blood flow is diverted to the brain from peripheral organs with high basal flow, such as the kidney. To explore these questions, total and regional cerebral blood flow (CBF) were measured in brain structures of the central autonomic network in anesthetized rats in HBO2 at 6 ATA. Electroencephalogram (EEG) recordings, cardiovascular hemodynamics, and renal blood flow (RBF) were also monitored. As expected, mean arterial blood pressure and total and regional CBF increased preceding EEG spikes while RBF was unaltered. Of the brain structures examined, the earliest rise in CBF occurred in the striatum, suggesting increased neuronal activation. Continuous unilateral or bilateral striatal infusion of the nitric oxide synthase inhibitor N(ω)-nitro-L-arginine methyl ester attenuated CBF responses in that structure, but global EEG discharges persisted and did not differ from controls. Our novel findings indicate that: 1) cerebral hyperemia in extreme HBO2 in rats does not occur at the expense of renal perfusion, highlighting the remarkable autoregulatory capability of the kidney, and 2) in spite of a sentinel increase in striatal blood flow, additional brain structure(s) likely govern the pathogenesis of HBO2-induced seizures because EEG discharge latency was unchanged by local blockade of striatal nitric oxide production and concomitant hyperemia.

Duke Scholars

Published In

J Appl Physiol (1985)

DOI

EISSN

1522-1601

Publication Date

December 1, 2015

Volume

119

Issue

11

Start / End Page

1282 / 1288

Location

United States

Related Subject Headings

  • Seizures
  • Renal Circulation
  • Rats, Sprague-Dawley
  • Rats
  • Physiology
  • Nitric Oxide Synthase Type I
  • Nitric Oxide
  • Neostriatum
  • NG-Nitroarginine Methyl Ester
  • Male
 

Citation

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Gasier, H. G., Demchenko, I. T., Allen, B. W., & Piantadosi, C. A. (2015). Effects of striatal nitric oxide production on regional cerebral blood flow and seizure development in rats exposed to extreme hyperoxia. J Appl Physiol (1985), 119(11), 1282–1288. https://doi.org/10.1152/japplphysiol.00432.2015
Gasier, Heath G., Ivan T. Demchenko, Barry W. Allen, and Claude A. Piantadosi. “Effects of striatal nitric oxide production on regional cerebral blood flow and seizure development in rats exposed to extreme hyperoxia.J Appl Physiol (1985) 119, no. 11 (December 1, 2015): 1282–88. https://doi.org/10.1152/japplphysiol.00432.2015.
Gasier HG, Demchenko IT, Allen BW, Piantadosi CA. Effects of striatal nitric oxide production on regional cerebral blood flow and seizure development in rats exposed to extreme hyperoxia. J Appl Physiol (1985). 2015 Dec 1;119(11):1282–8.
Gasier, Heath G., et al. “Effects of striatal nitric oxide production on regional cerebral blood flow and seizure development in rats exposed to extreme hyperoxia.J Appl Physiol (1985), vol. 119, no. 11, Dec. 2015, pp. 1282–88. Pubmed, doi:10.1152/japplphysiol.00432.2015.
Gasier HG, Demchenko IT, Allen BW, Piantadosi CA. Effects of striatal nitric oxide production on regional cerebral blood flow and seizure development in rats exposed to extreme hyperoxia. J Appl Physiol (1985). 2015 Dec 1;119(11):1282–1288.

Published In

J Appl Physiol (1985)

DOI

EISSN

1522-1601

Publication Date

December 1, 2015

Volume

119

Issue

11

Start / End Page

1282 / 1288

Location

United States

Related Subject Headings

  • Seizures
  • Renal Circulation
  • Rats, Sprague-Dawley
  • Rats
  • Physiology
  • Nitric Oxide Synthase Type I
  • Nitric Oxide
  • Neostriatum
  • NG-Nitroarginine Methyl Ester
  • Male