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In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models.

Publication ,  Journal Article
Register, JK; Fales, AM; Wang, H-N; Norton, SJ; Cho, EH; Boico, A; Pradhan, S; Kim, J; Schroeder, T; Wisniewski, NA; Klitzman, B; Vo-Dinh, T
Published in: Anal Bioanal Chem
November 2015

Surface-enhanced Raman scattering (SERS)-active plasmonic nanomaterials have become a promising agent for molecular imaging and multiplex detection. Among the wide variety of plasmonics-active nanoparticles, gold nanostars offer unique plasmon properties that efficiently induce strong SERS signals. Furthermore, nanostars, with their small core size and multiple long thin branches, exhibit high absorption cross sections that are tunable in the near-infrared region of the tissue optical window, rendering them efficient for in vivo spectroscopic detection. This study investigated the use of SERS-encoded gold nanostars for in vivo detection. Ex vivo measurements were performed using human skin grafts to investigate the detection of SERS-encoded nanostars through tissue. We also integrated gold nanostars into a biocompatible scaffold to aid in performing in vivo spectroscopic analyses. In this study, for the first time, we demonstrate in vivo SERS detection of gold nanostars using small animal (rat) as well as large animal (pig) models. The results of this study establish the usefulness and potential of SERS-encoded gold nanostars for future use in long-term in vivo analyte sensing.

Duke Scholars

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Published In

Anal Bioanal Chem

DOI

EISSN

1618-2650

Publication Date

November 2015

Volume

407

Issue

27

Start / End Page

8215 / 8224

Location

Germany

Related Subject Headings

  • Tissue Scaffolds
  • Swine
  • Spectrum Analysis, Raman
  • Skin Transplantation
  • Skin
  • Rats, Sprague-Dawley
  • Polyhydroxyethyl Methacrylate
  • Nanostructures
  • Models, Animal
  • Male
 

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Register, J. K., Fales, A. M., Wang, H.-N., Norton, S. J., Cho, E. H., Boico, A., … Vo-Dinh, T. (2015). In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models. Anal Bioanal Chem, 407(27), 8215–8224. https://doi.org/10.1007/s00216-015-8939-0
Register, Janna K., Andrew M. Fales, Hsin-Neng Wang, Stephen J. Norton, Eugenia H. Cho, Alina Boico, Sulolit Pradhan, et al. “In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models.Anal Bioanal Chem 407, no. 27 (November 2015): 8215–24. https://doi.org/10.1007/s00216-015-8939-0.
Register JK, Fales AM, Wang H-N, Norton SJ, Cho EH, Boico A, et al. In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models. Anal Bioanal Chem. 2015 Nov;407(27):8215–24.
Register, Janna K., et al. “In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models.Anal Bioanal Chem, vol. 407, no. 27, Nov. 2015, pp. 8215–24. Pubmed, doi:10.1007/s00216-015-8939-0.
Register JK, Fales AM, Wang H-N, Norton SJ, Cho EH, Boico A, Pradhan S, Kim J, Schroeder T, Wisniewski NA, Klitzman B, Vo-Dinh T. In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models. Anal Bioanal Chem. 2015 Nov;407(27):8215–8224.
Journal cover image

Published In

Anal Bioanal Chem

DOI

EISSN

1618-2650

Publication Date

November 2015

Volume

407

Issue

27

Start / End Page

8215 / 8224

Location

Germany

Related Subject Headings

  • Tissue Scaffolds
  • Swine
  • Spectrum Analysis, Raman
  • Skin Transplantation
  • Skin
  • Rats, Sprague-Dawley
  • Polyhydroxyethyl Methacrylate
  • Nanostructures
  • Models, Animal
  • Male