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Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus.

Publication ,  Journal Article
Sun, JM; Grant, GA; McLaughlin, C; Allison, J; Fitzgerald, A; Waters-Pick, B; Kurtzberg, J
Published in: Pediatr Res
December 2015

BACKGROUND: Babies with congenital hydrocephalus often experience developmental disabilities due to brain injury associated with prolonged increased pressure on the developing brain parenchyma. Umbilical cord blood (CB) infusion has favorable effects in animal models of brain hypoxia and stroke and is being investigated in clinical trials of brain injury in both children and adults. We sought to establish the safety and feasibility of repeated intravenous infusions of autologous CB in young babies with congenital hydrocephalus. METHODS: Infants with severe congenital hydrocephalus and an available qualified autologous CB unit traveled to Duke for evaluation and CB infusion. When possible, the CB unit was utilized for multiple infusions. Patient and CB data were obtained at the time of infusion and analyzed retrospectively. RESULTS: From October 2006 to August 2014, 76 patients with congenital hydrocephalus received 143 autologous CB infusions. Most babies received repeated doses, for a total of two (n = 45), three (n = 18), or four (n = 4) infusions. There were no infusion-related adverse events. As expected, all babies experienced developmental delays. CONCLUSION: Cryopreserved CB products may be effectively manipulated to provide multiple CB doses. Repeated intravenous infusion of autologous CB is safe and feasible in young babies with congenital hydrocephalus.

Duke Scholars

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Published In

Pediatr Res

DOI

EISSN

1530-0447

Publication Date

December 2015

Volume

78

Issue

6

Start / End Page

712 / 716

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Time Factors
  • Retrospective Studies
  • Reoperation
  • Pediatrics
  • North Carolina
  • Male
  • Infant, Newborn
  • Infant
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sun, J. M., Grant, G. A., McLaughlin, C., Allison, J., Fitzgerald, A., Waters-Pick, B., & Kurtzberg, J. (2015). Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus. Pediatr Res, 78(6), 712–716. https://doi.org/10.1038/pr.2015.161
Sun, Jessica M., Gerald A. Grant, Colleen McLaughlin, June Allison, Anne Fitzgerald, Barbara Waters-Pick, and Joanne Kurtzberg. “Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus.Pediatr Res 78, no. 6 (December 2015): 712–16. https://doi.org/10.1038/pr.2015.161.
Sun JM, Grant GA, McLaughlin C, Allison J, Fitzgerald A, Waters-Pick B, et al. Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus. Pediatr Res. 2015 Dec;78(6):712–6.
Sun, Jessica M., et al. “Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus.Pediatr Res, vol. 78, no. 6, Dec. 2015, pp. 712–16. Pubmed, doi:10.1038/pr.2015.161.
Sun JM, Grant GA, McLaughlin C, Allison J, Fitzgerald A, Waters-Pick B, Kurtzberg J. Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus. Pediatr Res. 2015 Dec;78(6):712–716.

Published In

Pediatr Res

DOI

EISSN

1530-0447

Publication Date

December 2015

Volume

78

Issue

6

Start / End Page

712 / 716

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Time Factors
  • Retrospective Studies
  • Reoperation
  • Pediatrics
  • North Carolina
  • Male
  • Infant, Newborn
  • Infant