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Association of maternal serum progesterone in early pregnancy with low birth weight and other adverse pregnancy outcomes.

Publication ,  Journal Article
He, S; Allen, JC; Malhotra, R; Østbye, T; Tan, TC
Published in: J Matern Fetal Neonatal Med
2016

OBJECTIVE: To investigate the association of serum progesterone in first trimester with low birth weight (LBW, birth weight <2500 g) and other adverse pregnancy outcomes including hypertensive disorders of pregnancy, preterm delivery, premature rupture of membranes at term, and preterm premature rupture of membranes in a general population. METHODS: We conducted a cohort study of 263 women with low-risk singleton intrauterine pregnancies who had a spot serum progesterone measurement in the first trimester in a Singapore tertiary maternity hospital. Study outcomes were retrieved from clinical records. Follow-up data were available for 131 women. Univariate and multivariate logistic regression analyses were performed to assess the association of low serum progesterone (<35 nmol/L) with LBW and other adverse pregnancy outcomes. RESULTS: Low serum progesterone was associated with a significantly increased risk of LBW (adjusted odds ratio: 5.28 [1.02, 27.3]; p=0.047). Low serum progesterone was associated with a significantly increased risk of hypertensive disorders of pregnancy in univariate analysis (unadjusted odds ratio: 8.43 [1.31, 54.2]; p=0.025). CONCLUSION: Low serum progesterone in the first trimester is a significant risk factor for LBW and possibly other placental dysfunction disorders such as hypertensive disorders of pregnancy. Further studies with larger sample sizes are needed to confirm the associations.

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Published In

J Matern Fetal Neonatal Med

DOI

EISSN

1476-4954

Publication Date

2016

Volume

29

Issue

12

Start / End Page

1999 / 2004

Location

England

Related Subject Headings

  • Progesterone
  • Pregnancy Trimester, First
  • Pregnancy Complications
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Male
  • Infant, Newborn
  • Infant, Low Birth Weight
  • Humans
  • Female
 

Citation

APA
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He, S., Allen, J. C., Malhotra, R., Østbye, T., & Tan, T. C. (2016). Association of maternal serum progesterone in early pregnancy with low birth weight and other adverse pregnancy outcomes. J Matern Fetal Neonatal Med, 29(12), 1999–2004. https://doi.org/10.3109/14767058.2015.1072159
He, Song, John Carson Allen, Rahul Malhotra, Truls Østbye, and Thiam Chye Tan. “Association of maternal serum progesterone in early pregnancy with low birth weight and other adverse pregnancy outcomes.J Matern Fetal Neonatal Med 29, no. 12 (2016): 1999–2004. https://doi.org/10.3109/14767058.2015.1072159.
He S, Allen JC, Malhotra R, Østbye T, Tan TC. Association of maternal serum progesterone in early pregnancy with low birth weight and other adverse pregnancy outcomes. J Matern Fetal Neonatal Med. 2016;29(12):1999–2004.
He, Song, et al. “Association of maternal serum progesterone in early pregnancy with low birth weight and other adverse pregnancy outcomes.J Matern Fetal Neonatal Med, vol. 29, no. 12, 2016, pp. 1999–2004. Pubmed, doi:10.3109/14767058.2015.1072159.
He S, Allen JC, Malhotra R, Østbye T, Tan TC. Association of maternal serum progesterone in early pregnancy with low birth weight and other adverse pregnancy outcomes. J Matern Fetal Neonatal Med. 2016;29(12):1999–2004.

Published In

J Matern Fetal Neonatal Med

DOI

EISSN

1476-4954

Publication Date

2016

Volume

29

Issue

12

Start / End Page

1999 / 2004

Location

England

Related Subject Headings

  • Progesterone
  • Pregnancy Trimester, First
  • Pregnancy Complications
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Male
  • Infant, Newborn
  • Infant, Low Birth Weight
  • Humans
  • Female