Modulation of the Coagulation Cascade Using Aptamers.

Journal Article (Review)

As a novel class of therapeutics, aptamers, or nucleic acid ligands, have garnered clinical interest because of the ease of isolating a highly specific aptamer against a wide range of targets, their chemical flexibility and synthesis, and their inherent ability to have their function reversed. The following review details the development and molecular mechanisms of aptamers targeting specific proteases in the coagulation cascade. The ability of these anticoagulant aptamers to bind to and inhibit exosite function rather than binding within the active site highlights the importance of exosites in blocking protein function. As both exosite inhibitors and reversible agents, the use of aptamers is a promising strategy for future therapeutics.

Full Text

Duke Authors

Cited Authors

  • Woodruff, RS; Sullenger, BA

Published Date

  • October 2015

Published In

Volume / Issue

  • 35 / 10

Start / End Page

  • 2083 - 2091

PubMed ID

  • 26315404

Electronic International Standard Serial Number (EISSN)

  • 1524-4636

International Standard Serial Number (ISSN)

  • 1079-5642

Digital Object Identifier (DOI)

  • 10.1161/atvbaha.115.300131

Language

  • eng