(18)F-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study.

Journal Article (Journal Article;Multicenter Study)

We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to International Harmonization Project criteria (IHP), Deauville 5-point scale (D 5PS) with scores 1-3 considered negative (D 5PS > 3) and D 5PS with scores 1-4 considered negative (D 5PS = 5). Ratios of tumor maximum standardized uptake value (SUVmax) to liver SUVmax were also analyzed. We found no difference in progression-free survival (PFS) between PET-negative and PET-positive patients according to IHP and D 5PS > 3. The 2-year PFS using D 5PS = 5 was 50.9% in the PET-positive group and 84.8% in the PET-negative group (p = 0.002). A tumor/liver SUVmax cut-off of 3.1 to distinguish D 5PS scores of 4 and 5 provided the best prognostic value. PET after one course of chemotherapy was not able to safely discriminate PET-positive and PET-negative patients in different prognostic groups.

Full Text

Duke Authors

Cited Authors

  • Mylam, KJ; Kostakoglu, L; Hutchings, M; Coleman, M; Lamonica, D; Czuczman, MS; Diehl, LF; Nielsen, AL; Jensen, P; Loft, A; Hendel, HW; Iyer, V; Leppä, S; Jyrkkiö, S; Holte, H; Eriksson, M; Gillstrøm, D; Hansen, PB; Seppänen, M; Hjorthaug, K; Brown, PDN; Pedersen, LM

Published Date

  • July 2015

Published In

Volume / Issue

  • 56 / 7

Start / End Page

  • 2005 - 2012

PubMed ID

  • 25330442

Electronic International Standard Serial Number (EISSN)

  • 1029-2403

Digital Object Identifier (DOI)

  • 10.3109/10428194.2014.975800


  • eng

Conference Location

  • United States