The current study examined whether peer social support, alone or in conjunction with peer delinquency, moderated the relations between overt and relational victimization, depressive symptoms, and rule-breaking behavior. Participants included 152 adolescents (55% male; 95% Latino) between the ages of 14–19 and their second-hour teacher. Findings indicated that peer social support buffered the association between relational victimization and depressive symptoms. Overt victimization was uniquely related to increased rule-breaking behavior, but unrelated to depressive symptoms. Peer social support and peer delinquency interacted to influence the association between relational victimization and rule-breaking behavior. When levels of both social support and peer delinquency were high, relational victimization marginally significantly predicted increased rule-breaking behavior. Relational victimization was unrelated to rule-breaking behavior when levels of peer delinquency were high and social support were low. The moderating effects of peer social support did not differ according to gender. Implications of findings and directions for future research are discussed.