Prokaryotic Systems Biology

Book Section (Chapter)

Prokaryotic systems biology is a holistic biological approach that enables comprehensive understanding of an organism. However, two opposing strategies have been proposed to attain such understanding: the top-down and bottom-up approaches. Here we present a review of the current status of the prokaryotic systems biology field against the backdrop of the top-down vs. bottom-up debate, including such topics as current experimental and computational methods and recent literature findings. We use four prokaryotic model systems as examples, including E. coli, Caulobacter crescentus, Halobacterium NRC-1, and Helicobacter pylori. We posit that systems biology programs which pursue an integrated combination of both approaches will be the most successful in attaining comprehensive systems-level understanding of prokaryotic model organisms.

Full Text

Duke Authors

Cited Authors

  • Schmid, AK; Baliga, NS

Cited Editors

  • Al-Rubeai, M; Fussenegger, M

Published Date

  • December 7, 2006

Volume / Issue

  • 5 /

Book Title

  • Systems Biology

Start / End Page

  • 395 - 423

Published By

International Standard Book Number 10 (ISBN-10)

  • 1402052510

International Standard Book Number 13 (ISBN-13)

  • 9781402052514