Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis.

Published

Journal Article

Although many vertebrate organs, such as kidneys, lungs and liver, are composed of epithelial tubules, little is known of the mechanisms that establish the length or diameter of these tubules. In the kidney, defects in the establishment or maintenance of tubule diameter are associated with one of the most common inherited human disorders, polycystic kidney disease. Here we show that attenuation of Wnt9b signaling during kidney morphogenesis affects the planar cell polarity of the epithelium and leads to tubules with significantly increased diameter. Although previous studies showed that polarized cell divisions maintain the diameter of postnatal kidney tubules, we find that cell divisions are randomly oriented during embryonic development. Our data suggest that diameter is established during early morphogenetic stages by convergent extension processes and maintained by polarized cell divisions. Wnt9b, signaling through the non-canonical Rho/Jnk branch of the Wnt pathway, is necessary for both of these processes.

Full Text

Duke Authors

Cited Authors

  • Karner, CM; Chirumamilla, R; Aoki, S; Igarashi, P; Wallingford, JB; Carroll, TJ

Published Date

  • July 2009

Published In

Volume / Issue

  • 41 / 7

Start / End Page

  • 793 - 799

PubMed ID

  • 19543268

Pubmed Central ID

  • 19543268

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng.400

Language

  • eng