Tankyrase is necessary for canonical Wnt signaling during kidney development.


Journal Article

Recent studies using small molecule antagonists have revealed that the poly(ADP-ribose) polymerases (PARPs) Tankyrase 1 and 2 are critical regulators of canonical Wnt signaling in some cellular contexts. However, the absence of any activity during zebrafish embryogenesis suggested that the tankyrases may not be general/core components of the Wnt pathway. Here, we show that Tnks1 and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt ligands. Tankyrase inhibition can be rescued by activation of beta-catenin demonstrating its specificity for the Wnt pathway. In addition, treatment with tankyrase inhibitors appears to be completely reversible in some cell types. These studies suggest that the tankyrases are core components of the canonical Wnt pathway and their inhibitors should enjoy broad usage as antagonists of Wnt signaling.

Full Text

Duke Authors

Cited Authors

  • Karner, CM; Merkel, CE; Dodge, M; Ma, Z; Lu, J; Chen, C; Lum, L; Carroll, TJ

Published Date

  • July 2010

Published In

Volume / Issue

  • 239 / 7

Start / End Page

  • 2014 - 2023

PubMed ID

  • 20549720

Pubmed Central ID

  • 20549720

Electronic International Standard Serial Number (EISSN)

  • 1097-0177

Digital Object Identifier (DOI)

  • 10.1002/dvdy.22340


  • eng

Conference Location

  • United States