This article focuses on Visualizing Venice, an interdisciplinary, cross-cultural collaboration that engages in mapping, 3-D modeling, and multimedia representations of historical change in Venice, Italy. Through a “laboratory” approach that integrates students and faculty in multi-year research teams, we ask new questions and pursue emerging lines of inquiry about architectural monuments, their relation to the larger urban setting, and the role of sculptural and painted decoration in sacred spaces. Our practice of digital art history transforms both teaching and research and provides new means for communicating knowledge to a broad public.