Skip to main content

Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: evidence from a meta-analysis.

Publication ,  Journal Article
He, J; Xi, B; Ruiter, R; Shi, T-Y; Zhu, M-L; Wang, M-Y; Li, Q-X; Zhou, X-Y; Qiu, L-X; Wei, Q-Y
Published in: PLoS One
2013

BACKGROUND: Numerous epidemiological studies have examined associations of genetic variations in LEP (G2548A, -2548 nucleotide upstream of the ATG start site) and LEPR (Q223R, nonsynonymous SNP in exon 6) with cancer susceptibility; however, the findings are inconsistent. Therefore, we performed a meta-analysis to comprehensively evaluate such associations. METHODS: We searched published literature from MEDLINE, EMBASE, Web of Science and CBM for eligible publications. We also assessed genotype-based mRNA expression data from HapMap for rs7799039 (G2548A) and rs1137101 (Q223R) in normal cell lines derived from 270 subjects with different ethnicities. RESULTS: The final analysis included 16 published studies of 6569 cases and 8405 controls for the LEP G2548A and 19 studies of 7504 cases and 9581 controls for the LEPR Q223R. Overall, LEP G2548A was statistically significantly associated with an increased risk of overall cancer (AA vs. GG: OR=1.27, 95% CI=1.05-1.54; recessive model: OR=1.19, 95% CI=1.00-1.41). Further stratifications by cancer type showed an increased risk for prostate cancer (recessive model: OR=1.26, 95% CI=1.05-1.51) but not for other cancers. For LEPR Q223R, no statistical evidence for an association with risk of cancer was found for all; however, further stratification by ethnicity showed an increased risk for Africans but not for other ethnicities. No significantly differences in LEP and LEPR mRNA expression were found among genotypes or by ethnicity. CONCLUSIONS: Despite some limitations, this meta-analysis found some statistical evidence for an association between the LEP 2548AA genotype and overall risk of cancer, particularly for prostate cancer, but given this variant did not have an effect on mRNA expression, this association warrants additional validation in large and well-designed studies.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

10

Start / End Page

e75135

Location

United States

Related Subject Headings

  • Receptors, Leptin
  • Racial Groups
  • RNA, Messenger
  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Neoplasms
  • Models, Genetic
  • Male
  • Leptin
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
He, J., Xi, B., Ruiter, R., Shi, T.-Y., Zhu, M.-L., Wang, M.-Y., … Wei, Q.-Y. (2013). Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: evidence from a meta-analysis. PLoS One, 8(10), e75135. https://doi.org/10.1371/journal.pone.0075135
He, Jing, Bo Xi, Rikje Ruiter, Ting-Yan Shi, Mei-Ling Zhu, Meng-Yun Wang, Qiao-Xin Li, Xiao-Yan Zhou, Li-Xin Qiu, and Qing-Yi Wei. “Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: evidence from a meta-analysis.PLoS One 8, no. 10 (2013): e75135. https://doi.org/10.1371/journal.pone.0075135.
He J, Xi B, Ruiter R, Shi T-Y, Zhu M-L, Wang M-Y, et al. Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: evidence from a meta-analysis. PLoS One. 2013;8(10):e75135.
He, Jing, et al. “Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: evidence from a meta-analysis.PLoS One, vol. 8, no. 10, 2013, p. e75135. Pubmed, doi:10.1371/journal.pone.0075135.
He J, Xi B, Ruiter R, Shi T-Y, Zhu M-L, Wang M-Y, Li Q-X, Zhou X-Y, Qiu L-X, Wei Q-Y. Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: evidence from a meta-analysis. PLoS One. 2013;8(10):e75135.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

10

Start / End Page

e75135

Location

United States

Related Subject Headings

  • Receptors, Leptin
  • Racial Groups
  • RNA, Messenger
  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Neoplasms
  • Models, Genetic
  • Male
  • Leptin
  • Humans