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An introduction to small non-coding RNAs: miRNA and snoRNA.

Publication ,  Journal Article
Holley, CL; Topkara, VK
Published in: Cardiovasc Drugs Ther
April 2011

Research into small non-coding RNAs (ncRNA) has fundamentally transformed our understanding of gene regulatory networks, especially at the post-transcriptional level. Although much is now known about the basic biology of small ncRNAs, our ability to recognize the impact of small ncRNA in disease states is preliminary, and the ability to effectively target them in vivo is very limited. However, given the larger and growing focus on targeting RNAs for disease therapeutics, what we do know about the intrinsic biology of these small RNAs makes them potentially attractive targets for pharmacologic manipulation. With that in mind, this review provides an introduction to the biology of small ncRNA, using microRNA (miRNA) and small nucleolar RNA (snoRNA) as examples.

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Published In

Cardiovasc Drugs Ther

DOI

EISSN

1573-7241

Publication Date

April 2011

Volume

25

Issue

2

Start / End Page

151 / 159

Location

United States

Related Subject Headings

  • RNA, Small Untranslated
  • RNA, Small Nucleolar
  • Molecular Targeted Therapy
  • MicroRNAs
  • Humans
  • Gene Regulatory Networks
  • Cardiovascular System & Hematology
  • 3214 Pharmacology and pharmaceutical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Holley, C. L., & Topkara, V. K. (2011). An introduction to small non-coding RNAs: miRNA and snoRNA. Cardiovasc Drugs Ther, 25(2), 151–159. https://doi.org/10.1007/s10557-011-6290-z
Holley, Christopher L., and Veli K. Topkara. “An introduction to small non-coding RNAs: miRNA and snoRNA.Cardiovasc Drugs Ther 25, no. 2 (April 2011): 151–59. https://doi.org/10.1007/s10557-011-6290-z.
Holley CL, Topkara VK. An introduction to small non-coding RNAs: miRNA and snoRNA. Cardiovasc Drugs Ther. 2011 Apr;25(2):151–9.
Holley, Christopher L., and Veli K. Topkara. “An introduction to small non-coding RNAs: miRNA and snoRNA.Cardiovasc Drugs Ther, vol. 25, no. 2, Apr. 2011, pp. 151–59. Pubmed, doi:10.1007/s10557-011-6290-z.
Holley CL, Topkara VK. An introduction to small non-coding RNAs: miRNA and snoRNA. Cardiovasc Drugs Ther. 2011 Apr;25(2):151–159.
Journal cover image

Published In

Cardiovasc Drugs Ther

DOI

EISSN

1573-7241

Publication Date

April 2011

Volume

25

Issue

2

Start / End Page

151 / 159

Location

United States

Related Subject Headings

  • RNA, Small Untranslated
  • RNA, Small Nucleolar
  • Molecular Targeted Therapy
  • MicroRNAs
  • Humans
  • Gene Regulatory Networks
  • Cardiovascular System & Hematology
  • 3214 Pharmacology and pharmaceutical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1115 Pharmacology and Pharmaceutical Sciences