Identifying Barriers and Practical Solutions to Conducting Site-Based Research in North America: Exploring Acute Heart Failure Trials As a Case Study.

Journal Article (Journal Article;Review)

Although the prognosis of ambulatory heart failure (HF) has improved dramatically there have been few advances in the management of acute HF (AHF). Despite regional differences in patient characteristics, background therapy, and event rates, AHF clinical trial enrollment has transitioned from North America and Western Europe to Eastern Europe, South America, and Asia-Pacific where regulatory burden and cost of conducting research may be less prohibitive. It is unclear if the results of clinical trials conducted outside of North America are generalizable to US patient populations. This article uses AHF as a paradigm and identifies barriers and practical solutions to successfully conducting site-based research in North America.

Full Text

Duke Authors

Cited Authors

  • Ambrosy, AP; Mentz, RJ; Krishnamoorthy, A; Greene, SJ; Severance, HW

Published Date

  • October 2015

Published In

Volume / Issue

  • 11 / 4

Start / End Page

  • 581 - 589

PubMed ID

  • 26462098

International Standard Serial Number (ISSN)

  • 1551-7136

Digital Object Identifier (DOI)

  • 10.1016/j.hfc.2015.07.002


  • eng

Conference Location

  • United States