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Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.

Publication ,  Journal Article
Sliepen, K; Ozorowski, G; Burger, JA; van Montfort, T; Stunnenberg, M; LaBranche, C; Montefiori, DC; Moore, JP; Ward, AB; Sanders, RW
Published in: Retrovirology
September 26, 2015

BACKGROUND: Presenting vaccine antigens in particulate form can improve their immunogenicity by enhancing B cell activation. FINDINGS: We describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664). Trimer-bearing nanoparticles were significantly more immunogenic than trimers in both mice and rabbits. Furthermore, rabbits immunized with the trimer-bearing nanoparticles induced significantly higher neutralizing antibody responses against most tier 1A viruses, and higher responses (but not significantly), to several tier 1B viruses and the autologous tier 2 virus than when the same trimers were delivered as soluble proteins. CONCLUSIONS: This or other nanoparticle designs may be practical ways to improve the immunogenicity of envelope glycoprotein trimers.

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Published In

Retrovirology

DOI

EISSN

1742-4690

Publication Date

September 26, 2015

Volume

12

Start / End Page

82

Location

England

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Virology
  • Rabbits
  • Protein Multimerization
  • Nanoparticles
  • Mice
  • Immunization
  • Humans
  • HIV-1
  • HIV Antibodies
 

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Sliepen, K., Ozorowski, G., Burger, J. A., van Montfort, T., Stunnenberg, M., LaBranche, C., … Sanders, R. W. (2015). Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity. Retrovirology, 12, 82. https://doi.org/10.1186/s12977-015-0210-4
Sliepen, Kwinten, Gabriel Ozorowski, Judith A. Burger, Thijs van Montfort, Melissa Stunnenberg, Celia LaBranche, David C. Montefiori, John P. Moore, Andrew B. Ward, and Rogier W. Sanders. “Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.Retrovirology 12 (September 26, 2015): 82. https://doi.org/10.1186/s12977-015-0210-4.
Sliepen K, Ozorowski G, Burger JA, van Montfort T, Stunnenberg M, LaBranche C, et al. Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity. Retrovirology. 2015 Sep 26;12:82.
Sliepen, Kwinten, et al. “Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.Retrovirology, vol. 12, Sept. 2015, p. 82. Pubmed, doi:10.1186/s12977-015-0210-4.
Sliepen K, Ozorowski G, Burger JA, van Montfort T, Stunnenberg M, LaBranche C, Montefiori DC, Moore JP, Ward AB, Sanders RW. Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity. Retrovirology. 2015 Sep 26;12:82.
Journal cover image

Published In

Retrovirology

DOI

EISSN

1742-4690

Publication Date

September 26, 2015

Volume

12

Start / End Page

82

Location

England

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Virology
  • Rabbits
  • Protein Multimerization
  • Nanoparticles
  • Mice
  • Immunization
  • Humans
  • HIV-1
  • HIV Antibodies