Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.

Published online

Journal Article

BACKGROUND: Presenting vaccine antigens in particulate form can improve their immunogenicity by enhancing B cell activation. FINDINGS: We describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664). Trimer-bearing nanoparticles were significantly more immunogenic than trimers in both mice and rabbits. Furthermore, rabbits immunized with the trimer-bearing nanoparticles induced significantly higher neutralizing antibody responses against most tier 1A viruses, and higher responses (but not significantly), to several tier 1B viruses and the autologous tier 2 virus than when the same trimers were delivered as soluble proteins. CONCLUSIONS: This or other nanoparticle designs may be practical ways to improve the immunogenicity of envelope glycoprotein trimers.

Full Text

Duke Authors

Cited Authors

  • Sliepen, K; Ozorowski, G; Burger, JA; van Montfort, T; Stunnenberg, M; LaBranche, C; Montefiori, DC; Moore, JP; Ward, AB; Sanders, RW

Published Date

  • September 26, 2015

Published In

Volume / Issue

  • 12 /

Start / End Page

  • 82 -

PubMed ID

  • 26410741

Pubmed Central ID

  • 26410741

Electronic International Standard Serial Number (EISSN)

  • 1742-4690

Digital Object Identifier (DOI)

  • 10.1186/s12977-015-0210-4

Language

  • eng

Conference Location

  • England