Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.
BACKGROUND: Presenting vaccine antigens in particulate form can improve their immunogenicity by enhancing B cell activation. FINDINGS: We describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664). Trimer-bearing nanoparticles were significantly more immunogenic than trimers in both mice and rabbits. Furthermore, rabbits immunized with the trimer-bearing nanoparticles induced significantly higher neutralizing antibody responses against most tier 1A viruses, and higher responses (but not significantly), to several tier 1B viruses and the autologous tier 2 virus than when the same trimers were delivered as soluble proteins. CONCLUSIONS: This or other nanoparticle designs may be practical ways to improve the immunogenicity of envelope glycoprotein trimers.
Duke Scholars
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Related Subject Headings
- env Gene Products, Human Immunodeficiency Virus
- Virology
- Rabbits
- Protein Multimerization
- Nanoparticles
- Mice
- Immunization
- Humans
- HIV-1
- HIV Antibodies
Citation
Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- env Gene Products, Human Immunodeficiency Virus
- Virology
- Rabbits
- Protein Multimerization
- Nanoparticles
- Mice
- Immunization
- Humans
- HIV-1
- HIV Antibodies