Clinical trials in sudden cardiac death prevention: Principles and endpoints


Book Section

© Springer-Verlag London 2013. A properly designed and conducted randomized clinical trial is the most objective approach for definitive comparison of medical therapies. However, a clinical trial is a complex collaborative undertaking and requires substantial multidisciplinary planning efforts. This chapter presents the main components of a randomized trial and discusses the essential statistical concepts relevant in a trial design. The primary result and summary of statistical power, analysis, and the follow-up approach of the four recently completed pivotal clinical trials pertinent to the prevention of sudden cardiac death are summarized.

Full Text

Duke Authors

Cited Authors

  • Kosinski, AS

Published Date

  • January 1, 2013

Book Title

  • Electrical Diseases of the Heart: Volume 2: Diagnosis and Treatment, Second Edition

Start / End Page

  • 487 - 493

International Standard Book Number 13 (ISBN-13)

  • 9781447149774

Digital Object Identifier (DOI)

  • 10.1007/978-1-4471-4978-1_31

Citation Source

  • Scopus