Aptamers in the clinic

Journal Article (Review;Journal)

In 1990, an RNA molecule was designed that bound to a nucleic acid binding protein to act as a decoy, thereby preventing HIV replication. That same year, two research groups identified a high-throughput method to select for nucleic acids to protein targets and the field of aptamer therapeutics was born. Over the last 20 years, numerous aptamers to therapeutic targets have been isolated and undergone in vitro and ex vivo analysis before in vivo testing. Aptamer therapeutics represents a promising new class of agents to treat disease. The capability to extensively modify these compounds provides a potential broader spectrum of clinical applications than antibodies and small molecules. A brief historical review of aptamers is presented and the therapeutic aptamers currently in clinical development are described. Copyright © 2009 Prous Science, S.A.U. or its licensors. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Nimjee, SM; Sullenger, BA

Published Date

  • January 1, 2009

Published In

Volume / Issue

  • 34 / 11

Start / End Page

  • 897 - 901

International Standard Serial Number (ISSN)

  • 0377-8282

Digital Object Identifier (DOI)

  • 10.1358/dof.2009.034.11.1445907

Citation Source

  • Scopus