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A Non-Canonical Role for β-Secretase in the Retina.

Publication ,  Chapter
Qian, Q; Mitter, SK; Pay, SL; Qi, X; Rickman, CB; Grant, MB; Boulton, ME
2016

It has long been established that β-Secretase (BACE) plays a critical role in the formation of amyloid plaques in Alzheimer's Disease patients, but it is only recently that the importance of β-secretases in retinal pathophysiology has been recognized. BACE expression is elevated in response to stress, and downregulation results in lysosomal abnormalities and mitochondrial changes. Inhibition of BACE can lead to reduced retinal function, retinal thinning, lipofuscin accumulation and vascular dysfunction in mice. Furthermore, BACE inhibition accelerates choroidal neovascularization (CNV) in mice. We propose that BACE plays an important role in retinal homeostasis and that BACE upregulation in response to stress is a protective measure.

Duke Scholars

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DOI

Publication Date

2016

Volume

854

Start / End Page

333 / 339

Related Subject Headings

  • Retina
  • Mice
  • Macular Degeneration
  • Humans
  • Homeostasis
  • General & Internal Medicine
  • Disease Models, Animal
  • Diabetic Retinopathy
  • Aspartic Acid Endopeptidases
  • Animals
 

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Qian, Q., Mitter, S. K., Pay, S. L., Qi, X., Rickman, C. B., Grant, M. B., & Boulton, M. E. (2016). A Non-Canonical Role for β-Secretase in the Retina. (Vol. 854, pp. 333–339). https://doi.org/10.1007/978-3-319-17121-0_44
Qian, Qingwen, Sayak K. Mitter, S Louise Pay, Xiaoping Qi, Catherine Bowes Rickman, Maria B. Grant, and Michael E. Boulton. “A Non-Canonical Role for β-Secretase in the Retina.,” 854:333–39, 2016. https://doi.org/10.1007/978-3-319-17121-0_44.
Qian Q, Mitter SK, Pay SL, Qi X, Rickman CB, Grant MB, et al. A Non-Canonical Role for β-Secretase in the Retina. In 2016. p. 333–9.
Qian, Qingwen, et al. A Non-Canonical Role for β-Secretase in the Retina. Vol. 854, 2016, pp. 333–39. Pubmed, doi:10.1007/978-3-319-17121-0_44.
Qian Q, Mitter SK, Pay SL, Qi X, Rickman CB, Grant MB, Boulton ME. A Non-Canonical Role for β-Secretase in the Retina. 2016. p. 333–339.

DOI

Publication Date

2016

Volume

854

Start / End Page

333 / 339

Related Subject Headings

  • Retina
  • Mice
  • Macular Degeneration
  • Humans
  • Homeostasis
  • General & Internal Medicine
  • Disease Models, Animal
  • Diabetic Retinopathy
  • Aspartic Acid Endopeptidases
  • Animals