Evidence of a genetic link between endometriosis and ovarian cancer.
OBJECTIVE:To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer. DESIGN:Pooled genetic analysis. SETTING:University hospital. PATIENT(S):Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,815 controls) from 41 ovarian cancer studies. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Endometriosis-associated genetic variation and ovarian cancer. RESULT(S):There was significant evidence of an association between endometriosis-related genetic variation and ovarian cancer risk, especially for the high-grade serous and clear cell histotypes. Overall we observed 15 significant burden statistics, which was three times more than expected. CONCLUSION(S):By focusing on candidate regions from a phenotype associated with ovarian cancer, we have shown a clear genetic link between endometriosis and ovarian cancer that warrants further follow-up. The functional significance of the identified regions and SNPs is presently uncertain, though future fine mapping and histotype-specific functional analyses may shed light on the etiologies of both gynecologic conditions.
Lee, AW; Templeman, C; Stram, DA; Beesley, J; Tyrer, J; Berchuck, A; Pharoah, PP; Chenevix-Trench, G; Pearce, CL; Ovarian Cancer Association Consortium,
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