Individual patient data meta-analysis of self-monitoring of blood pressure (BP-SMART): a protocol.

Journal Article

INTRODUCTION: Self-monitoring of blood pressure is effective in reducing blood pressure in hypertension. However previous meta-analyses have shown a considerable amount of heterogeneity between studies, only part of which can be accounted for by meta-regression. This may be due to differences in design, recruited populations, intervention components or results among patient subgroups. To further investigate these differences, an individual patient data (IPD) meta-analysis of self-monitoring of blood pressure will be performed. METHODS AND ANALYSIS: We will identify randomised trials that have compared patients with hypertension who are self-monitoring blood pressure with those who are not and invite trialists to provide IPD including clinic and/or ambulatory systolic and diastolic blood pressure at baseline and all follow-up points where both intervention and control groups were measured. Other data requested will include measurement methodology, length of follow-up, cointerventions, baseline demographic (age, gender) and psychosocial factors (deprivation, quality of life), setting, intensity of self-monitoring, self-monitored blood pressure, comorbidities, lifestyle factors (weight, smoking) and presence or not of antihypertensive treatment. Data on all available patients will be included in order to take an intention-to-treat approach. A two-stage procedure for IPD meta-analysis, stratified by trial and taking into account age, sex, diabetes and baseline systolic BP will be used. Exploratory subgroup analyses will further investigate non-linear relationships between the prespecified variables. Sensitivity analyses will assess the impact of trials which have and have not provided IPD. ETHICS AND DISSEMINATION: This study does not include identifiable data. Results will be disseminated in a peer-reviewed publication and by international conference presentations. CONCLUSIONS: IPD analysis should help the understanding of which self-monitoring interventions for which patient groups are most effective in the control of blood pressure.

Full Text

Duke Authors

Cited Authors

  • Tucker, KL; Sheppard, JP; Stevens, R; Bosworth, HB; Bove, A; Bray, EP; Godwin, M; Green, B; Hebert, P; Hobbs, FDR; Kantola, I; Kerry, S; Magid, DJ; Mant, J; Margolis, KL; McKinstry, B; Omboni, S; Ogedegbe, O; Parati, G; Qamar, N; Varis, J; Verberk, W; Wakefield, BJ; McManus, RJ

Published Date

  • September 15, 2015

Published In

Volume / Issue

  • 5 / 9

Start / End Page

  • e008532 -

PubMed ID

  • 26373404

Pubmed Central ID

  • 26373404

Electronic International Standard Serial Number (EISSN)

  • 2044-6055

Digital Object Identifier (DOI)

  • 10.1136/bmjopen-2015-008532


  • eng

Conference Location

  • England