Baseline Antihypertensive Drug Count and Patient Response to Hypertension Medication Management.

Journal Article

Telemedicine-based medication management improves hypertension control, but has been evaluated primarily in patients with low antihypertensive drug counts. Its impact on patients taking three or more antihypertensive agents is not well-established. To address this evidence gap, the authors conducted an exploratory analysis of an 18-month, 591-patient trial of telemedicine-based hypertension medication management. Using general linear models, the effect of medication management on blood pressure for patients taking two or fewer antihypertensive agents at study baseline vs those taking three or more was compared. While patients taking two or fewer antihypertensive agents had a significant reduction in systolic blood pressure with medication management, those taking three or more had no such response. The between-subgroup effect difference was statistically significant at 6 months (-6.4 mm Hg [95% confidence interval, -12.2 to -0.6]) and near significant at 18 months (-6.0 mm Hg [95% confidence interval, -12.2 to 0.2]). These findings suggest that baseline antihypertensive drug count may impact how patients respond to hypertension medication management and emphasize the need to study management strategies specifically in patients taking three or more antihypertensive medications.

Full Text

Duke Authors

Cited Authors

  • Crowley, MJ; Olsen, MK; Woolson, SL; King, HA; Oddone, EZ; Bosworth, HB

Published Date

  • April 2016

Published In

Volume / Issue

  • 18 / 4

Start / End Page

  • 322 - 328

PubMed ID

  • 26370918

Electronic International Standard Serial Number (EISSN)

  • 1751-7176

International Standard Serial Number (ISSN)

  • 1524-6175

Digital Object Identifier (DOI)

  • 10.1111/jch.12669

Language

  • eng