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Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke.

Publication ,  Journal Article
Brown, CM; Bushnell, CD; Samsa, GP; Goldstein, LB; Colton, CA
Published in: Transl Stroke Res
December 2015

The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 weeks post-stroke compared to control individuals. Cases were African-Americans with lacunar stroke (n = 30), and controls were age-matched African-Americans with no history of stroke or other major neurologic disease (n = 37). Blood was obtained >6 weeks post-stroke and was analyzed for inflammatory biomarkers. Freshly isolated peripheral blood mononuclear cells were stimulated with lipopolysaccharide (LPS) to assess immune responsiveness in a subset of cases (n = 5) and controls (n = 4). After adjustment for covariates, the pro-inflammatory biomarkers, soluble vascular cadherin adhesion molecule-1 (sVCAM-1) and thrombin anti-thrombin (TAT), were independently associated with lacunar stroke. Immune responsiveness to LPS challenge was abnormal in cases compared to controls. African-Americans with lacunar stroke had elevated blood levels of VCAM-1 and TAT and an abnormal response to acute immune challenge >6 weeks post-stroke, suggesting a chronically compromised systemic inflammatory response.

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Published In

Transl Stroke Res

DOI

EISSN

1868-601X

Publication Date

December 2015

Volume

6

Issue

6

Start / End Page

430 / 436

Location

United States

Related Subject Headings

  • Vascular Cell Adhesion Molecule-1
  • Stroke, Lacunar
  • Middle Aged
  • Male
  • Inflammation Mediators
  • Inflammation
  • Humans
  • Gene Products, tat
  • Female
  • Chronic Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Brown, C. M., Bushnell, C. D., Samsa, G. P., Goldstein, L. B., & Colton, C. A. (2015). Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke. Transl Stroke Res, 6(6), 430–436. https://doi.org/10.1007/s12975-015-0424-8
Brown, Candice M., Cheryl D. Bushnell, Gregory P. Samsa, Larry B. Goldstein, and Carol A. Colton. “Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke.Transl Stroke Res 6, no. 6 (December 2015): 430–36. https://doi.org/10.1007/s12975-015-0424-8.
Brown CM, Bushnell CD, Samsa GP, Goldstein LB, Colton CA. Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke. Transl Stroke Res. 2015 Dec;6(6):430–6.
Brown, Candice M., et al. “Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke.Transl Stroke Res, vol. 6, no. 6, Dec. 2015, pp. 430–36. Pubmed, doi:10.1007/s12975-015-0424-8.
Brown CM, Bushnell CD, Samsa GP, Goldstein LB, Colton CA. Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke. Transl Stroke Res. 2015 Dec;6(6):430–436.
Journal cover image

Published In

Transl Stroke Res

DOI

EISSN

1868-601X

Publication Date

December 2015

Volume

6

Issue

6

Start / End Page

430 / 436

Location

United States

Related Subject Headings

  • Vascular Cell Adhesion Molecule-1
  • Stroke, Lacunar
  • Middle Aged
  • Male
  • Inflammation Mediators
  • Inflammation
  • Humans
  • Gene Products, tat
  • Female
  • Chronic Disease