Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke.

Published

Journal Article

The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 weeks post-stroke compared to control individuals. Cases were African-Americans with lacunar stroke (n = 30), and controls were age-matched African-Americans with no history of stroke or other major neurologic disease (n = 37). Blood was obtained >6 weeks post-stroke and was analyzed for inflammatory biomarkers. Freshly isolated peripheral blood mononuclear cells were stimulated with lipopolysaccharide (LPS) to assess immune responsiveness in a subset of cases (n = 5) and controls (n = 4). After adjustment for covariates, the pro-inflammatory biomarkers, soluble vascular cadherin adhesion molecule-1 (sVCAM-1) and thrombin anti-thrombin (TAT), were independently associated with lacunar stroke. Immune responsiveness to LPS challenge was abnormal in cases compared to controls. African-Americans with lacunar stroke had elevated blood levels of VCAM-1 and TAT and an abnormal response to acute immune challenge >6 weeks post-stroke, suggesting a chronically compromised systemic inflammatory response.

Full Text

Duke Authors

Cited Authors

  • Brown, CM; Bushnell, CD; Samsa, GP; Goldstein, LB; Colton, CA

Published Date

  • December 2015

Published In

Volume / Issue

  • 6 / 6

Start / End Page

  • 430 - 436

PubMed ID

  • 26373290

Pubmed Central ID

  • 26373290

Electronic International Standard Serial Number (EISSN)

  • 1868-601X

Digital Object Identifier (DOI)

  • 10.1007/s12975-015-0424-8

Language

  • eng

Conference Location

  • United States