Defining treatment response in trichotillomania: a signal detection analysis.

Journal Article

The Massachusetts General Hospital Hairpulling Scale (MGH-HPS) and the NIMH Trichotillomania Severity Scale (NIMH-TSS) are two widely used measures of trichotillomania severity. Despite their popular use, currently no empirically-supported guidelines exist to determine the degrees of change on these scales that best indicate treatment response. Determination of such criteria could aid in clinical decision-making by defining clinically significant treatment response/recovery and producing accurate power analyses for use in clinical trials research. Adults with trichotillomania (N=69) participated in a randomized controlled trial of psychotherapy and were assessed before and after treatment. Response status was measured via the Clinical Global Impressions-Improvement Scale, and remission status was measured via the Clinical Global Impressions-Severity Scale. For treatment response, a 45% reduction or 7-point raw score change on the MGH-HPS was the best indicator of clinically significant treatment response, and on the NIMH-TSS, a 30-40% reduction or 6-point raw score difference was most effective cutoff. For disorder remission, a 55-60% reduction or 7-point raw score change on the MGH-HPS was the best predictor, and on the NIMH-TSS, a 65% reduction or 6-point raw score change was the best indicator of disorder remission. Implications of these findings are discussed.

Full Text

Duke Authors

Cited Authors

  • Houghton, DC; Capriotti, MR; De Nadai, AS; Compton, SN; Twohig, MP; Neal-Barnett, AM; Saunders, SM; Franklin, ME; Woods, DW

Published Date

  • December 2015

Published In

Volume / Issue

  • 36 /

Start / End Page

  • 44 - 51

PubMed ID

  • 26422605

Electronic International Standard Serial Number (EISSN)

  • 1873-7897

International Standard Serial Number (ISSN)

  • 0887-6185

Digital Object Identifier (DOI)

  • 10.1016/j.janxdis.2015.09.008

Language

  • eng