Genes and environment in neonatal intraventricular hemorrhage.

Journal Article (Journal Article;Review)

Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

Full Text

Duke Authors

Cited Authors

  • Ment, LR; Ådén, U; Bauer, CR; Bada, HS; Carlo, WA; Kaiser, JR; Lin, A; Cotten, CM; Murray, J; Page, G; Hallman, M; Lifton, RP; Zhang, H; Gene Targets for IVH Study Group and the Neonatal Research Network,

Published Date

  • December 2015

Published In

Volume / Issue

  • 39 / 8

Start / End Page

  • 592 - 603

PubMed ID

  • 26516117

Pubmed Central ID

  • PMC4668116

Electronic International Standard Serial Number (EISSN)

  • 1558-075X

Digital Object Identifier (DOI)

  • 10.1053/j.semperi.2015.09.006


  • eng

Conference Location

  • United States