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Genes and environment in neonatal intraventricular hemorrhage.

Publication ,  Journal Article
Ment, LR; Ådén, U; Bauer, CR; Bada, HS; Carlo, WA; Kaiser, JR; Lin, A; Cotten, CM; Murray, J; Page, G; Hallman, M; Lifton, RP; Zhang, H ...
Published in: Semin Perinatol
December 2015

Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

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Published In

Semin Perinatol

DOI

EISSN

1558-075X

Publication Date

December 2015

Volume

39

Issue

8

Start / End Page

592 / 603

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Intracranial Hemorrhages
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans
  • Gestational Age
 

Citation

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Ment, L. R., Ådén, U., Bauer, C. R., Bada, H. S., Carlo, W. A., Kaiser, J. R., … Gene Targets for IVH Study Group and the Neonatal Research Network, . (2015). Genes and environment in neonatal intraventricular hemorrhage. Semin Perinatol, 39(8), 592–603. https://doi.org/10.1053/j.semperi.2015.09.006
Ment, Laura R., Ulrika Ådén, Charles R. Bauer, Henrietta S. Bada, Waldemar A. Carlo, Jeffrey R. Kaiser, Aiping Lin, et al. “Genes and environment in neonatal intraventricular hemorrhage.Semin Perinatol 39, no. 8 (December 2015): 592–603. https://doi.org/10.1053/j.semperi.2015.09.006.
Ment LR, Ådén U, Bauer CR, Bada HS, Carlo WA, Kaiser JR, et al. Genes and environment in neonatal intraventricular hemorrhage. Semin Perinatol. 2015 Dec;39(8):592–603.
Ment, Laura R., et al. “Genes and environment in neonatal intraventricular hemorrhage.Semin Perinatol, vol. 39, no. 8, Dec. 2015, pp. 592–603. Pubmed, doi:10.1053/j.semperi.2015.09.006.
Ment LR, Ådén U, Bauer CR, Bada HS, Carlo WA, Kaiser JR, Lin A, Cotten CM, Murray J, Page G, Hallman M, Lifton RP, Zhang H, Gene Targets for IVH Study Group and the Neonatal Research Network. Genes and environment in neonatal intraventricular hemorrhage. Semin Perinatol. 2015 Dec;39(8):592–603.
Journal cover image

Published In

Semin Perinatol

DOI

EISSN

1558-075X

Publication Date

December 2015

Volume

39

Issue

8

Start / End Page

592 / 603

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Intracranial Hemorrhages
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans
  • Gestational Age