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Elucidating the role of genomics in neonatal sepsis.

Publication ,  Journal Article
Srinivasan, L; Kirpalani, H; Cotten, CM
Published in: Semin Perinatol
December 2015

Sepsis is a major cause of neonatal morbidity and mortality, especially in vulnerable preterm populations. Immature immune defenses, and environmental and maternal factors contribute to this risk, with as many as a third of very preterm infants experiencing sepsis during their stay in the neonatal intensive care unit (NICU). Epidemiologic and twin studies have suggested that there is a genetic contribution to sepsis predilection. Several investigators have conducted candidate gene association studies on variants of specific interest and potential functional significance in neonatal sepsis. In this review, we describe details of studies that have evaluated genetic susceptibility in neonatal sepsis, and summarize findings from a review of candidate gene association studies.

Duke Scholars

Published In

Semin Perinatol

DOI

EISSN

1558-075X

Publication Date

December 2015

Volume

39

Issue

8

Start / End Page

611 / 616

Location

United States

Related Subject Headings

  • United States
  • Sepsis
  • Receptors, Immunologic
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Premature
 

Citation

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Srinivasan, L., Kirpalani, H., & Cotten, C. M. (2015). Elucidating the role of genomics in neonatal sepsis. Semin Perinatol, 39(8), 611–616. https://doi.org/10.1053/j.semperi.2015.09.008
Srinivasan, Lakshmi, Haresh Kirpalani, and Charles Michael Cotten. “Elucidating the role of genomics in neonatal sepsis.Semin Perinatol 39, no. 8 (December 2015): 611–16. https://doi.org/10.1053/j.semperi.2015.09.008.
Srinivasan L, Kirpalani H, Cotten CM. Elucidating the role of genomics in neonatal sepsis. Semin Perinatol. 2015 Dec;39(8):611–6.
Srinivasan, Lakshmi, et al. “Elucidating the role of genomics in neonatal sepsis.Semin Perinatol, vol. 39, no. 8, Dec. 2015, pp. 611–16. Pubmed, doi:10.1053/j.semperi.2015.09.008.
Srinivasan L, Kirpalani H, Cotten CM. Elucidating the role of genomics in neonatal sepsis. Semin Perinatol. 2015 Dec;39(8):611–616.
Journal cover image

Published In

Semin Perinatol

DOI

EISSN

1558-075X

Publication Date

December 2015

Volume

39

Issue

8

Start / End Page

611 / 616

Location

United States

Related Subject Headings

  • United States
  • Sepsis
  • Receptors, Immunologic
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Premature