Oxygen supplementation, delivery, and physiologic effects


Book Section

© Springer-Verlag Berlin Heidelberg 2015. The delivery of oxygen is a vital component of patient care within pediatric and neonatal intensive care units. Clinicians are constantly altering the support provided to each patient in an attempt to optimize oxygen delivery as defined by the following equation: DO2=CO × arterial O2content arterial O2content=(SaO2saturation × 1.39 (mL/g) × Hb) + (0.003 × PaO2) where DO2represents oxygen delivery; CO, cardiac output; SaO2, arterial oxygen saturation; Hb, hemoglobin; and PaO2, partial pressure of oxygen in arterial blood. Thus, decreased oxygen delivery can result from inadequate cardiac output, low arterial oxygen saturation, inadequate hemoglobin concentration, or low PaO2as a minor contributor (secondary to the factor of 0.003 in the formula outlined above). In this chapter, we will review the variety of mechanisms by which clinicians can improve the supply of oxygen to the patient to meet the metabolic demands involved with various pathophysiologic processes.

Full Text

Duke Authors

Cited Authors

  • Peterson-Carmichael, S; Cheifetz, I; Storme, L

Published Date

  • January 1, 2015

Book Title

  • Pediatric and Neonatal Mechanical Ventilation: From Basics to Clinical Practice

Start / End Page

  • 123 - 134

International Standard Book Number 13 (ISBN-13)

  • 9783642012181

Digital Object Identifier (DOI)

  • 10.1007/978-3-642-01219-8_6

Citation Source

  • Scopus