Marked gender differences in progression of mild cognitive impairment over 8 years.

Journal Article (Journal Article)

INTRODUCTION: This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. METHODS: We examine longitudinal rates of change from baseline in 398 MCI subjects (141 Females, 257 Males) in the Alzheimer's Disease Neuroimaging Initiative-1 (ADNI-1), followed for up to 8 years (mean 4.1±2.5 years) using mixed effects models incorporating all follow ups (mean 8±4 visits). RESULTS: Women progressed at faster rates than men on ADAS-Cog (p=0.001) and CDR-SB (p=0.003). Quadratic fit for change over time was significant for both ADAS-Cog (p=0.001) and CDR-SB (p=0.004), and the additional acceleration in women was 100% for ADAS-Cog and 143% for CDR-SB. The variability of change was greater in women. The gender effect was greater in ApoE4 carriers. DISCUSSION: Women with MCI have greater longitudinal rates of cognitive and functional progression than men. Studies to confirm and uncover potential mechanisms appear to be warranted.

Full Text

Duke Authors

Cited Authors

  • Lin, KA; Choudhury, KR; Rathakrishnan, BG; Marks, DM; Petrella, JR; Doraiswamy, PM; Alzheimer's Disease Neuroimaging Initiative,

Published Date

  • September 1, 2015

Published In

Volume / Issue

  • 1 / 2

Start / End Page

  • 103 - 110

PubMed ID

  • 26451386

Pubmed Central ID

  • PMC4593067

International Standard Serial Number (ISSN)

  • 2352-8737

Digital Object Identifier (DOI)

  • 10.1016/j.trci.2015.07.001


  • eng

Conference Location

  • United States