Marked gender differences in progression of mild cognitive impairment over 8 years.
This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men.We examine longitudinal rates of change from baseline in 398 MCI subjects (141 Females, 257 Males) in the Alzheimer's Disease Neuroimaging Initiative-1 (ADNI-1), followed for up to 8 years (mean 4.1±2.5 years) using mixed effects models incorporating all follow ups (mean 8±4 visits).Women progressed at faster rates than men on ADAS-Cog (p=0.001) and CDR-SB (p=0.003). Quadratic fit for change over time was significant for both ADAS-Cog (p=0.001) and CDR-SB (p=0.004), and the additional acceleration in women was 100% for ADAS-Cog and 143% for CDR-SB. The variability of change was greater in women. The gender effect was greater in ApoE4 carriers.Women with MCI have greater longitudinal rates of cognitive and functional progression than men. Studies to confirm and uncover potential mechanisms appear to be warranted.
Lin, KA; Choudhury, KR; Rathakrishnan, BG; Marks, DM; Petrella, JR; Doraiswamy, PM; Alzheimer's Disease Neuroimaging Initiative,
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