Mode of Death After Acute Heart Failure Hospitalization - A Clue to Possible Mechanisms.

Journal Article (Journal Article;Review)

Heart failure continues to be a leading cause of hospitalization worldwide, and acute heart failure (AHF) carries significant risk for short-term morbidity and mortality. Despite many trials of potential new therapies for AHF, there have been very few advances over the recent decades. In this review, we will examine mortality during and after AHF hospitalization, with an emphasis on available data on mode of death (MOD). We will also review data on the timing of different MOD after AHF and the effect of specific therapies, as well as what is known about the contribution of specific pathophysiological mechanisms. Finally, we discuss the potential utility of further study of MOD data for AHF and its application to drug development, risk stratification, and therapeutic tailoring to improve short- and long-term outcomes in AHF.

Full Text

Duke Authors

Cited Authors

  • Parikh, KS; Felker, GM; Metra, M

Published Date

  • 2016

Published In

Volume / Issue

  • 80 / 1

Start / End Page

  • 17 - 23

PubMed ID

  • 26511229

Electronic International Standard Serial Number (EISSN)

  • 1347-4820

Digital Object Identifier (DOI)

  • 10.1253/circj.CJ-15-1006


  • eng

Conference Location

  • Japan