Efficient imaging of midbrain nuclei using inverse double-echo steady-state acquisition.


Journal Article

PURPOSE: Imaging of midbrain nuclei using T2- or T2*-weighted MRI often entails long echo time, leading to long scan time. In this study, an inverse double-echo steady-state (iDESS) technique is proposed for efficiently depicting midbrain nuclei. METHODS: Thirteen healthy subjects participated in this study. iDESS was performed along with two sets of T2*-weighted spoiled gradient-echo images (SPGR1, with scan time identical to iDESS and SPGR2, using clinical scanning parameters as a reference standard) for comparison. Generation of iDESS composite images combining two echo signals was optimized for maximal contrast-to-noise ratio (CNR) between the red nuclei and surrounding tissues. Signal-to-noise ratios (SNRs) were calculated from the occipital lobe. Comparison was also made using phase-enhanced images as in standard susceptibility-weighted imaging (SWI). RESULTS: The iDESS images present significantly higher SNR efficiency (171.3) than SPGR1 (158.7, p = 0.013) and SPGR2 (95.5, p < 10(-8)). iDESS CNR efficiency (19.2) is also significantly greater than SPGR1 (6.9, p < 10(-6)) and SPGR2 (14.3, p = 0.0016). Compared with DESS, iDESS provides further advantage on enhanced phase information and hence improved contrast on SWI-processed images. CONCLUSIONS: iDESS efficiently depicts midbrain nuclei with improved CNR efficiency, increased SNR efficiency, and reduced scan time and is less prone to susceptibility signal loss from air-tissue interfaces.

Full Text

Cited Authors

  • Wu, M-L; Chang, H-C; Chao, T-C; Chen, N-K

Published Date

  • July 2015

Published In

Volume / Issue

  • 42 / 7

Start / End Page

  • 4367 - 4374

PubMed ID

  • 26133633

Pubmed Central ID

  • 26133633

Electronic International Standard Serial Number (EISSN)

  • 2473-4209

Digital Object Identifier (DOI)

  • 10.1118/1.4922402


  • eng

Conference Location

  • United States