Current State of Reporting Pain Outcomes in Cochrane Reviews of Chronic Musculoskeletal Pain Conditions and Considerations for an OMERACT Research Agenda.

Journal Article (Journal Article)

OBJECTIVE: To assess the current state of reporting of pain outcomes in Cochrane reviews on chronic musculoskeletal painful conditions and to elicit opinions of patients, healthcare practitioners, and methodologists on presenting pain outcomes to patients, clinicians, and policymakers. METHODS: We identified all reviews in the Cochrane Library of chronic musculoskeletal pain conditions from Cochrane review groups (Back, Musculoskeletal, and Pain, Palliative, and Supportive Care) that contained a summary of findings (SoF) table. We extracted data on reported pain domains and instruments and conducted a survey and interviews on considerations for SoF tables (e.g., pain domains, presentation of results). RESULTS: Fifty-seven SoF tables in 133 Cochrane reviews were eligible. SoF tables reported pain in 56/57, with all presenting results for pain intensity (20 different outcome instruments), pain interference in 8 SoF tables (5 different outcome instruments), and pain frequency in 1 multiple domain instrument. Other domains like pain quality or pain affect were not reported. From the survey and interviews [response rate 80% (36/45)], we derived 4 themes for a future research agenda: pain domains, considerations for assessing truth, discrimination, and feasibility; clinically important thresholds for responder analyses and presenting results; and establishing hierarchies of outcome instruments. CONCLUSION: There is a lack of standardization in the domains of pain selected and the manner that pain outcomes are reported in SoF tables, hampering efforts to synthesize evidence. Future research should focus on the themes identified, building partnerships to achieve consensus and develop guidance on best practices for reporting pain outcomes.

Full Text

Duke Authors

Cited Authors

  • Maxwell, LJ; Wells, GA; Simon, LS; Conaghan, PG; Grosskleg, S; Scrivens, K; Beaton, DE; Bingham, CO; Busse, JW; Christensen, R; Goel, N; Jüni, P; Kaiser, U; Lyddiatt, A; Mease, PJ; Ostelo, RW; Phillips, K; Sapunar, D; Singh, JA; Strand, V; Taylor, AM; Terwee, CB; Tugwell, P

Published Date

  • October 2015

Published In

Volume / Issue

  • 42 / 10

Start / End Page

  • 1934 - 1942

PubMed ID

  • 26373562

Pubmed Central ID

  • PMC6649665

International Standard Serial Number (ISSN)

  • 0315-162X

Digital Object Identifier (DOI)

  • 10.3899/jrheum.141423


  • eng

Conference Location

  • Canada