Intra-aortic balloon counterpulsation reduces mortality in large anterior myocardial infarction complicated by persistent ischaemia: A CRISP-AMI substudy

Journal Article (Journal Article)

© Europa Digital & Publishing 2015. All rights reserved. Aims: This substudy investigated IABP support in large STEMI complicated by persistent ischaemia within the original CRISP-AMI trial. Methods and results: Patients were included if the ECG at admission showed summed ST deviation (∑ST-D) ≥15 mm and the ECG post PCI showed poor ST resolution ( < 50%). Endpoints evaluated were all-cause mortality at six months and the composite endpoint of death, cardiogenic shock or new or worsening heart failure at six months. One hundred and forty-nine patients had ∑ST-D ≥15 mm (mean ∑ST-D 24±8 mm). Of these patients, 36 (24%) showed poor ST resolution (15 patients in the IABP group; 21 patients in the control group). Mean age was 55±11 years, 89% were male. Mean systolic and diastolic blood pressures were 135±31 mmHg and 83±22 mmHg, respectively. The left anterior descending coronary artery was the infarct-related artery in all cases, primary PCI was successful in 94%. At six months, zero patients in the IABP group died versus five patients in the control group (0% versus 24%; p=0.046). There was a trend towards statistical significance in the composite endpoint (one patient [7%] versus seven patients [33%] ; p=0.06). Conclusions: In this substudy, use of IABP was associated with decreased six-month mortality in large STEMI complicated by persistent ischaemia after PCI.

Full Text

Duke Authors

Cited Authors

  • Van Nunen, LX; Van 'TVeer, M; Schampaert, S; Rutten, MCM; Van De Vosse, FN; Patel, MR; Pijls, NHJ

Published Date

  • January 1, 2015

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 286 - 292

Electronic International Standard Serial Number (EISSN)

  • 1969-6213

International Standard Serial Number (ISSN)

  • 1774-024X

Digital Object Identifier (DOI)

  • 10.4244/EIJY14M09-10

Citation Source

  • Scopus