Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population.

Journal Article (Journal Article)

Published data on the association between PRKAA1 rs13361707 T > C polymorphism and gastric cancer (GCa) susceptibility were inconclusive. To derive a more precise estimation of the association, we conducted a large-scale GCa study of 1,124 cases and 1,194 controls to confirm this association in an eastern Chinese population. Our results showed that the C allele of PRKAA1 rs13361707 increased the GC risk in the study population [CT vs. TT, odds ratio (OR) = 1.72, 95% confidence interval (CI) = 1.40-2.12; CC vs. TT, OR = 2.15, 95%CI = 1.70-2.71; CT/CC vs. TT, OR = 1.86, 95%CI = 1.53-2.26; CC vs.TT/CT, OR = 1.49, 95%CI = 1.24-1.79]. In addition, the association of C allele with an increased GCa risk was still significant in subgroups, when stratified by age, sex, tumor site, drinking and smoking status. Moreover, the findings in the present study were validated by our further meta-analysis. In summary, these results indicated that the C allele of PRKAA1 rs13361707 was a low-penetrate risk factor for GCa.

Full Text

Duke Authors

Cited Authors

  • Qiu, L-X; He, J; Cheng, L; Zhou, F; Wang, M-Y; Sun, M-H; Zhou, X-Y; Li, J; Guo, W-J; Wang, Y-N; Yang, Y-J; Wang, J-C; Jin, L; Zhu, X-D; Wei, Q-Y

Published Date

  • December 15, 2015

Published In

Volume / Issue

  • 6 / 40

Start / End Page

  • 42661 - 42666

PubMed ID

  • 26485766

Pubmed Central ID

  • PMC4767461

Electronic International Standard Serial Number (EISSN)

  • 1949-2553

Digital Object Identifier (DOI)

  • 10.18632/oncotarget.6124


  • eng

Conference Location

  • United States