Lab-on-a-disk immunoassay for ocular diagnostics

Conference Paper

Monitoring of angiogenic cytokines in the eyes of patients with diabetic retinopathy (DR) and age-related macular degeneration (AMD) is crucial to confirm efficacy of treatment. We present a novel 'lab-on-a-disk' immunoassay for monitoring vascular endothelial growth factor in the eye with potential for deployment at the ophthalmologist's office as a point-of-care diagnostic. Using rudimentary sedimentation principles, the immunoassay can be completed in a two-step method within 16-18 minutes. The platform is comparable in sensitivity to conventional ELISA. Adoption of this platform at the point-of-care will facilitate accurate dosing of anti-angiogenic medication used to treat DR and AMD as well as identify non-responders.

Full Text

Duke Authors

Cited Authors

  • Walsh, DI; Murthy, SK; Hahn, PS; Jaffe, GJ; Sommer, GJ; Schaff, UY

Published Date

  • January 1, 2014

Published In

Volume / Issue

  • 2014-December /

Electronic International Standard Serial Number (EISSN)

  • 2160-7001

International Standard Serial Number (ISSN)

  • 1071-121X

International Standard Book Number 13 (ISBN-13)

  • 9781479937288

Digital Object Identifier (DOI)

  • 10.1109/NEBEC.2014.6972966

Citation Source

  • Scopus