© 2015 Elsevier Inc. All rights reserved. Regenerative medicine is dedicated to the study of repairing, replacing, or regenerating damaged human cells, tissues, or organs to restore or establish normal function, and it is predicted to develop into numerous applications to treat a wide variety of conditions. Umbilical cord blood (CB) is a relatively safe, easily collected, readily available, and noncontroversial source of stem and progenitor cells for use in standard hematopoietic stem cell transplantation. It has also recently emerged as a promising source of stem and progenitor cells for use in novel cell therapies. In this chapter, we will explore some of the potential applications of CB in regenerative medicine.