Intra-arterial Reserpine for Raynaud's Syndrome: Systemic Reactions Without Therapeutic Benefit


Journal Article

• Twenty-four patients classified as having Raynaud's disease or Raynaud's phenomenon were given bilateral brachial artery injections of reserpine or saline in a double-blind fashion. In the six weeks following injection, there was no indication that reserpine produced clinical improvement or changed vasomotor reactivity in the treated patients. However, intra-arterial reserpine did produce systemic cardiovascular effects lasting up to six weeks. It is concluded that intra-arterial reserpine as used in this study is an ineffective treatment for Raynaud's disease or Raynaud's phenomenon and may have significant adverse effects. © 1983, American Medical Association. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Surwit, RS; Gilgor, RS; Duvic, M; Allen, LM; Neal, JA

Published Date

  • 1983-01-01

Published In

Volume / Issue

  • 119 / 9

Start / End Page

  • 733 - 735

Electronic International Standard Serial Number (EISSN)

  • 1538-3652

International Standard Serial Number (ISSN)

  • 0003-987X

Digital Object Identifier (DOI)

  • 10.1001/archderm.1983.01650330025008

Citation Source

  • Scopus