Condition for alternans and its control in a two-dimensional mapping model of paced cardiac dynamics


Journal Article

A two-dimensional mapping model of a paced, isolated cardiac cell, which relates the duration of the action potential to the two preceding diastolic intervals as well as the preceding action potential duration, was studied. The model that was used displayed a rate-dependent restitution and memory. A control was initiated by carrying forward small adjustments to the pacing interval in order to suppress the alternans and stabilize the 1:1 response pattern displayed by the model. The gain that is necessary to establish control was shown to vary siginificantly depending on the value of the slope of the standard restitution curve.

Full Text

Duke Authors

Cited Authors

  • Tolkacheva, EG; Romeo, MM; Guerraty, M; Gauthier, DJ

Published Date

  • 2004-03-01

Published In

Volume / Issue

  • 69 / 3 1

International Standard Serial Number (ISSN)

  • 1063-651X

Digital Object Identifier (DOI)

  • 10.1103/PhysRevE.69.031904

Citation Source

  • Scopus