Taming Amphotericin B.

Journal Article

A strategy is introduced for enhancing the cellular selectivity of Amphotericin B (AmB) and other classes of membrane-disrupting agents. This strategy involves attaching the agent to a molecular umbrella to minimize the disruptive power of aggregated forms. Based on this approach, AmB has been coupled to a molecular umbrella derived from one spermidine and two cholic acid molecules and found to have antifungal activities approaching that of the native drug. However, in sharp contrast to AmB, the hemolytic activity and the cytotoxcity of this conjugate toward HEK293 T cells have been dramatically reduced.

Full Text

Duke Authors

Cited Authors

  • Janout, V; Schell, WA; Thévenin, D; Yu, Y; Perfect, JR; Regen, SL

Published Date

  • October 2015

Published In

Volume / Issue

  • 26 / 10

Start / End Page

  • 2021 - 2024

PubMed ID

  • 26340430

Electronic International Standard Serial Number (EISSN)

  • 1520-4812

International Standard Serial Number (ISSN)

  • 1043-1802

Digital Object Identifier (DOI)

  • 10.1021/acs.bioconjchem.5b00463

Language

  • eng